Chloroacetyl chloride → 2-chloro-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide
反応式
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([O:17][CH3:18])=[C:7]([CH:9]([OH:16])[CH2:10][NH:11][C:12]([CH2:14]N)=[O:13])[CH:8]=1.Cl.[Cl:20]CC(Cl)=O>>[Cl:20][CH2:14][C:12]([NH:11][CH2:10][CH:9]([C:7]1[CH:8]=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][C:6]=1[O:17][CH3:18])[OH:16])=[O:13]参加物
3
実験手順
The synthesis of Midodrine HCl consists of reacting the key intermediate (2) with chloroacetyl chloride to afford 2-chloro-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide (3). The reaction of (3) with sodium azide will provide 2-azido-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide (4) which is subsequently subjected to hydrogenation to afford Midodrine base (6).
出典と根拠
- ORDレコード
- ord-224076de90a54dcca9a3d01e0dc9c907
- 出典データセット
- uspto-grants-2003_08
- 特許番号
- US06610886B2
反応ノート
読み込み中…