Citric Acid → Florfenicol Flunixin

HRID 1666773

反応式

HRID 1666773 の反応式
C(O)(=O)CC(CC(O)=O)(C(O)=O)O.C(O)C(O)C.C1OCOC1CO.[CH3:26][S:27]([C:30]1[CH:31]=[CH:32][C:33]([C@@H:36]([OH:46])[C@H:37]([NH:40][C:41]([CH:43]([Cl:45])[Cl:44])=[O:42])[CH2:38][F:39])=[CH:34][CH:35]=1)(=[O:29])=[O:28].[CH3:47][C:48]1[C:53]([NH:54][C:55]2[N:60]=[CH:59][CH:58]=[CH:57][C:56]=2[C:61]([OH:63])=[O:62])=[CH:52][CH:51]=[CH:50][C:49]=1[C:64]([F:67])([F:66])[F:65].CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO>CC(N(C)C)=O.CN1C(=O)CCC1>[CH3:26][S:27]([C:30]1[CH:31]=[CH:32][C:33]([C@@H:36]([OH:46])[C@H:37]([NH:40][C:41]([CH:43]([Cl:45])[Cl:44])=[O:42])[CH2:38][F:39])=[CH:34][CH:35]=1)(=[O:29])=[O:28].[CH3:47][C:48]1[C:53]([NH:54][C:55]2[N:60]=[CH:59][CH:58]=[CH:57][C:56]=2[C:61]([OH:63])=[O:62])=[CH:52][CH:51]=[CH:50][C:49]=1[C:64]([F:66])([F:65])[F:67]

参加物

8

反応物 5

HCID 311Citric AcidHCID 1030Propylene GlycolHCID 216181,3-Dioxolane-4-methanol2 回HCID 39212Flunixin MeglumineHCID 114811Florfenicol

生成物 1

HCID 86602307Florfenicol Flunixin

試薬・触媒・溶媒 2

HCID 13387N-methyl-2-pyrrolidone溶媒HCID 31374Dimethylacetamide溶媒

実験手順

The NMP or dimethylacetamide, citric acid, propylene glycol, and approximately 90% of the PEG 300 or glycerol formal required for each formulation were charged to the compounding vessel and mixed well. The florfenicol and flunixin meglumine were added with mixing until all solids were dissolved. The volume was adjusted with the remaining PEG 300 or glycerol formal.

後処理

  1. additionwere charged to the compounding vessel
  2. additionmixed well
  3. additionwith mixing until all solids
  4. dissolutionwere dissolved

出典と根拠

ORDレコード
ord-f33629d272154f038dc051a2ce161aaf
出典データセット
uspto-grants-2011_10
特許番号
US08044102B2

関連ノート

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