Phosphonic acid (HCID 407)

名称と識別子

優先名称: Phosphonic acid
IUPAC: phosphonic acid
現地名: ホスホン酸
英語名: Phosphorous acid
分子式: H3O3P
分子量: 82

名称と別名

RefChem:6132DTXCID6029674237-066-713598-36-2CHEBI:44976DTXSID2049715Phosphonic acidPhosphorus trihydroxideホスホン酸ホスホン酸標準品亜リン亜リン酸 SOLUTION ≥50%

名称をさらに表示

亜りん酸, 98+%亜リン酸溶液亜りん酸, 97%亜りん酸標準品Phosphorous acidPHOSPHORUS ACIDPhosphorous acid 99%PhosphonsurePhospohorous acidPhosphorous Acid CrystalPhosphorous acid, extra pure, 98%Phosphorous acid, 98%, extra pureH3PO3

データベース識別子

CAS: 13598-36-2
PubChem CID: 407
DTXSID: DTXSID2049715
ChEMBL: CHEMBL1235291
EC Number: 237-066-7

物性

構造計算による物性

XLogP: -1.6
極性表面積: 57.5 Å²
水素結合供与体数: 2
水素結合受容体数: 3
回転可能結合数: 0
重原子数: 4
形式電荷: 0
複雑度: 26

実験および物理化学的性質

Physical DescriptionDry Powder; Liquid; Liquid; Large Crystals; CBI; Dry Powder

物理化学的性質

融点: 73 °C · 73 °C
沸点: 200 °C · 200 °C
比重(密度): 1.651 g/mL · 1.651 g/mL at 25 °C(lit.)
蒸気圧: 0.001 Pa · 0.001Pa at 20℃
闪点: 200 °C · 200°C
貯蔵温度: 0 · 0-6°C
溶解性: DMSO (Slightly), Methanol (Slightly), Water (Sparingly)
外見: クリスタル
酸解離定数(Pka): 1 · pK1 1.29; pK2 6.74(at 25℃)
比重: 1.651 · 1.651
色: 白い
PH: 1 · pKa1= 1.10, pKa2 = 6.33(25℃)
水溶解度: 溶ける
Merck: 14 · 14,7346
安定性: 安定。強塩基とは相容れない。吸湿性。
InChI: 1S/H3O3P/c1-4(2)3/h4H,(H2,1,2,3)
InChIKey: ABLZXFCXXLZCGV-UHFFFAOYSA-N
SMILES: [H]P(O)(O)=O
CAS データベース: 13598 · 13598-36-2(CAS DataBase Reference)
NISTの化学物質情報: 2 HPO · (HO)2HPO(13598-36-2)
EPAの化学物質情報: Phosphonic acid (13598-36-2)

化学的性質 · 1 件

化学的特性Phosphorous acid is a white crystalline deliquescent solid that can be prepared by the action of water on phosphorus( III) oxide or phosphorus(III) chloride. It is a dibasic acid producing the anions H2PO3- and HPO3 2- in water. The acid and its salts are slow reducing agents. On warming, phosphonic acid decomposes to phosphine and phosphoric(V) acid. Phosphorus acid is used to prepare phosphite salts. It is usually sold as a 20% aqueous solution.

安全と法規制

GHS分類

GHS Classification · 6 件

Danger

H302: Harmful if swallowed [Warning Acute toxicity, oral]；H314: Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]

P260, P264, P270, P280, P301+P317, P301+P330+P331, P302+P361+P354, P304+P340, P305+P354+P338, P316, P321, P330, P363, P405, and P501 (click each P-code to see the statement)

This chemical does not meet GHS hazard criteria for 0.1% (2 of 1718) of reports.

危険有害性情報

Regulatory Information · 6 件

Chemical: Phosphonic acid

Commission Regulation No 844/2012

Phosphonic acid is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Phosphonic acid are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 16-02-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15806

Ortho phosphorous acid: Does not have an individual approval but may be used under an appropriate group standard

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

Other Safety InformationIMAP assessments - Phosphonic acid: Human health tier II assessment；IMAP assessments - Phosphonic acid: Environment tier I assessment

EPA Safer Chemical · 1 件

Chemical: Phosphonic acid； Yellow triangle - The chemical has met Safer Choice Criteria for its functional ingredient-class, but has some hazard profile issues. Specifically, a chemical with this code is not associated with a low level of hazard concern for all human health and environmental endpoints. (See Safer Choice Criteria). While it is a best-in-class chemical and among the safest available for a particular function, the function fulfilled by the chemical should be considered an area for safer chemistry innovation.

Hazard Classes and Categories · 5 件

Met. Corr. 1 (22.3%)；Acute Tox. 4 (98.6%)；Skin Corr. 1 (99.9%)；Eye Dam. 1 (47.1%)；STOT SE 3 (26%)

Acute toxicity - category 4；Skin corrosion - category 1A

Self-reactive substances and mixtures - Type G；Acute toxicity (Oral) - Category 4；Skin corrosion/irritation - Category 1；Serious eye damage/eye irritation - Category 1

Corrosives

Acute Tox. 4 *；Skin Corr. 1A

安全と保護具

Protective Action Criteria (PAC) · 3 件

5.7 [mg/m3]

63 [mg/m3]

380 [mg/m3]

法規制情報

Regulatory Information · 6 件

Chemical: Phosphonic acid

Commission Regulation No 844/2012

Phosphonic acid is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of Phosphonic acid are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 16-02-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15806

Ortho phosphorous acid: Does not have an individual approval but may be used under an appropriate group standard

The New Jersey Worker and Community Right to Know Act requires public and private employers to provide information about hazardous substances at their workplaces. (N.J.S.A. 34:5A-1 et. seq.)

安全データ

F: 3
wgk: 1
tsca: TSCA listed
rtecs: SZ6400000
ridadr: UN 2834
hs_code: 28092019
risk_code: 22-35
hazard_code: C
safety_code: 26-36/37/39-45
hazard_class: 8
packing_group: III
毒劇物取締法: III
Hazard Classifications: Acute Tox. 4 OralEye Dam. 1Met. Corr. 1Skin Corr. 1A
ストレージクラス: 8A - Combustible corrosive hazardous materials

化学と産業

用途と製造

U.S. Production2023: 10,000,000 - <25,000,000 lb；2022: 10,000,000 - <25,000,000 lb；2021: 25,000,000 - <40,000,000 lb；2020: 10,000,000 - <25,000,000 lb

Consumer UsesNot Known or Reasonably Ascertainable；Soil amendments (fertilizers)；Intermediate

Industry Uses · 1 件

CBI；Processing aids not otherwise specified；Reducing agent；Soil amendments (fertilizers)；Not Known or Reasonably Ascertainable；Corrosion inhibitor；Flocculating agent；Intermediate；Anti-scaling agent；Processing aids, specific to petroleum production

Household ProductsInformation on 6 consumer products that contain Phosphorus acid in the following categories is provided:；• Auto Products；• Inside the Home；• Landscaping/Yard；• Personal Care

Use Classification · 2 件

EPA Safer Chemical Functional Use Classes -> Oxidants and Oxidant Stabilizers

Safer Chemical Classes -> Yellow triangle - The chemical has met Safer Choice Criteria for its functional ingredient-class, but has some hazard profile issues

General Manufacturing Information · 2 件

All Other Basic Organic Chemical Manufacturing；Miscellaneous Manufacturing；Paper Manufacturing；Not Known or Reasonably Ascertainable；All Other Chemical Product and Preparation Manufacturing；Agriculture, Forestry, Fishing and Hunting；Soap, Cleaning Compound, and Toilet Preparation Manufacturing；Oil and Gas Drilling, Extraction, and Support activities；Pesticide, Fertilizer, and Other Agricultural Chemical Manufacturing；CBI；Mining (except Oil and Gas) and support activities

Phosphonic acid: ACTIVE

応用分野 · 6 件

解説ホスホン酸，四面体形の [PHO3]2- を含む二塩基酸。 H3PO3 と書いて，亜リン酸と称していたことがあったが，これは誤称。無色，潮解性結晶，比重 1.65 。還元性が強く，貴金属塩から金属を遊離する。アルカリ塩およびカルシウム塩のほかは水に難溶。なお，ホスホン酸とオルトリン酸とが脱水縮合して生成する酸に相当するものとして次リン酸などが知られている。ブリタニカ国際大百科事典小項目事典ブリタニカ

用途塩化ビニル安定剤、有機合成触媒、pH 調整剤、ポリエステルフィルムの表面処理剤、分析（水銀検出）、還元剤、亜リン酸塩製造（肥料等）.

説明Phosphorous acid, H3PO3, is diprotic (readily ionizes two protons), not triprotic as might be suggested by this formula. Phosphorous acid is as an intermediate in the preparation of other phosphorous compounds. Because preparation and uses of “phosphorous acid” actually pertain more to the major tautomer, phosphonic acid, it is more often referred to as “phosphorous acid”. Phosphorous acid has the chemical formula H3PO3, which is best expressed as HPO(OH)2 to show its diprotic character. P(OH)3 (IUPAC: phosphorous acid) has CAS number 10294-56-1. It has been shown to be a stable tautomer.

使用Phosphorous acid is used to produce the fertilizer phosphate salt like potassium phosphite, ammonium phosphite and calcium phosphite. It is actively involved in the preparation of phosphites like aminotris(methylenephosphonic acid) (ATMP), 1-hydroxyethane 1,1-diphosphonic acid (HEDP) and 2-phosphonobutane-1,2,4-tricarboxylic Acid (PBTC), which find application in water treatment as a scale or corrosive inhibitor. It is also used in chemical reactions as a reducing agent. Its salt, lead phosphite is used as PVC stabilizer. It is also used as a precursor in the preparation of phosphine and as an intermediate in the preparation of other phosphorus compounds.

一般的な説明Phosphorous acid appears as a white or yellow crystalline solid (melting point 70.1°C) or a solution of the solid. Density 1.651 g /cm3 . Contact may severely irritate skin, eyes, and mucous membranes. Toxic by ingestion, inhalation and skin absorption.

使用用途ホスホン酸は還元性が強いため、無電解めっきの還元剤としての使用可能です。やの水溶液から、それぞれ銀やを析出させて、メッキを施せます。 P-アルキルホスホン酸ジアルキルエステル (R-P(=O)(OR')2)は、工業的に重要な中間体です。P-アルキルホスホン酸ジアルキルエステルはホーナー・ワズワース・エモンズ反応 (英: Horner–Wadsworth–Emmons reaction) の基質であり、ホーナー・エモンズ試薬と呼ばれ、アルケンの原料になります。ホーナー・エモンズ試薬は、香料や医薬品の原料として、多方面で使用されています。

調製方法 · 1 件

製造方法Phosphorus acid can be prepared by the reaction of phosphorus trichloride with water: PCl3 + 3H2O → H3PO4 + 3HClThe reaction is violent. Addition of PCl3 should be extremely cautious and slow. The addition can be carried out safely in the presence of concentrated HCl. Alternatively, a stream of air containing PCl3 vapor is passed into icecold water and solid crystals of H3PO4 form. Alternatively, phosphorus acid can be prepared by adding phosphorus trichloride to anhydrous oxalic acid: PCl3 + 3(COOH）2 → H3PO3 + 3CO + 3CO2 + 3HCl In this reaction, all products except H3PO3 escape as gases leaving the liquid acid. Dissolution of phosphorus sesquioxide in water also forms phosphorus acid. When shaken with ice water, phosphorus acid is the only product . P4O6 + 6H2O → 4H3PO3 However, in hot water part of the phosphorus acid disproportionates to phosphoric acid and phosphorus or phosphine.