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Use water spray to cool unopened containers.

For small (incipient) fires, use media such as "alcohol" foam, dry chemical, or carbon dioxide. For large fires, apply water from as far as possible. Use very large quantities (flooding) of water applied as a mist or spray; solid streams of water may be ineffective. Cool all affected containers with flooding quantities of water.

Wear self contained breathing apparatus for fire fighting if necessary. Use water spray to cool unopened containers.

Extinguishing methods: alcohol resisitant fire fighting foam

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Store under inert gas.

ACCIDENTAL RELEASE MEASURES: Personal precautions, protective equipment and emergency procedures: Use personal protective equipment. Avoid breathing vapors, mist or gas. Remove all sources of ignition. Beware of vapors accumulating to form explosive concentrations. Vapors can accumulate in low areas. Environmental precautions: Prevent further leakage or spillage if safe to do so. Do not let product enter drains.

Contain spillage, and then collect with an electrically protected vacuum cleaner or by wet-brushing and place in container for disposal according to local regulations.

SRP: Recycle any unused portion of the material for its approved use or return it to the manufacturer or supplier. Ultimate disposal of the chemical must consider: the material's impact on air quality; potential migration in air, soil or water; effects on animal, aquatic and plant life; and conformance with environmental and public health regulations. If it is possible or reasonable use an alternative chemical product with less inherent propensity for occupational harm/injury/toxicity or environmental contamination.

Product: Burn in a chemical incinerator equipped with an afterburner and scrubber but exert extra care in igniting as this material is highly flammable. Offer surplus and non-recyclable solutions to a licensed disposal company. Contaminated packaging: Dispose of as unused product.

Avoid inhalation of vapor or mist. Keep away from sources of ignition - No smoking. Take measures to prevent the build up of electrostatic charge.

Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.

Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.

Residues of 3-hexen-1-ol, (3Z)- are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest. Use: Odorant, alerting agent. Limit: Not more than 0.4% of the pesticide formulation.

Residues of the following chemical substances are exempted from the requirement of a tolerance when used in accordance with good manufacturing practice as ingredients in an antimicrobial pesticide formulation, provided that the substance is applied on a semi-permanent or permanent food-contact surface (other than being applied on food packaging) with adequate draining before contact with food. (a) The following chemical substances when used as ingredients in an antimicrobial pesticide formulation may be applied to: Food-contact surfaces in public eating places, dairy-processing equipment, and food-processing equipment and utensils. (Z)-3-Hexenol is included on this list. Limit: When ready for use, the end-use concentration is not to exceed 100 ppm.

Respiratory protection: Where risk assessment shows air-purifying respirators are appropriate, use a full-face respirator with multipurpose combination (US) or type ABEK (EN 14387) respirator cartridges as a backup to engineering controls. If the respirator is the sole means of protection, use a full-face supplied air respirator. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).

Body Protection: Wear impervious, flame retardant, antistatic protective clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.

Skin protection: Handle with gloves.

Eye/face protection: Face shield and safety glasses, use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).

EC50; Species: Xenopus laevis (African Clawed Frog) embryo; Conditions: freshwater, static, 23 °C; Concentration: 3.25 mmol/L for 96 hr (95% confidence interval: 2.5-5 mmol/L); Effect: development, increased deformation /> or = 95% purity/

LC50; Species: Xenopus laevis (African Clawed Frog) age 5 days tadpole; Conditions: freshwater, renewal, 23 °C; Concentration: 2.23 mmol/L for 96 hr (95% confidence interval: 2-2.5 mmol/L) /> or = 95% purity/

LC50; Species: Xenopus laevis (African Clawed Frog) embryo; Conditions: freshwater, static, 23 °C; Concentration: 8.41 mmol/L for 96 hr (95% confidence interval: 7.5-10 mmol/L) /> or = 95% purity/

LC50; Species: Pimephales promelas (Fathead Minnow) age 29-33 days, juvenile, weight 119 mg, length 19.7 mm; Conditions: freshwater, flow through, 24.8 °C, pH 7.69, hardness 44.5 mg/L CaCO3, alkalinity 43.2 mg/L CaCO3, dissolved oxygen 6.9 mg/L; Concentration: 381000 ug/L for 96 hr (95% confidence interval: 352000-412000 ug/L) /> or = 95% purity/

For more Ecotoxicity Values (Complete) data for 3-Hexenol (6 total), please visit the HSDB record page.

TERRESTRIAL FATE: Based on a classification scheme(1), an estimated Koc value of 12(SRC), determined from a structure estimation method(2), indicates that cis-3-hexen-1-ol is expected to have very high mobility in soil(SRC). Volatilization of cis-3-hexen-1-ol from moist soil surfaces is expected to be an important fate process(SRC) given an estimated Henry's Law constant of 1.6X10-5 atm-cu m/mole(SRC), using a fragment constant estimation method(2). cis-3-Hexen-1-ol is expected to volatilize from dry soil surfaces(SRC) based upon an estimated vapor pressure of 0.94 mm Hg at 25 °C(SRC), determined from a fragment constant method(2). An 87% of theoretical BOD using activated sludge in the Japanese MITI test(3) suggests that biodegradation is an important environmental fate process in soil(SRC). cis-3-Hexen-1-ol absorbs at wavelengths >290 nm(4) and, therefore, may be susceptible to direct photolysis on soil surfaces exposed to sunlight(SRC).

AQUATIC FATE: Based on a classification scheme(1), an estimated Koc value of 12(SRC), determined from a structure estimation method(2), indicates that cis-3-hexen-1-ol is not expected to adsorb to suspended solids and sediment(SRC). Volatilization from water surfaces is expected(3) based upon an estimated Henry's Law constant of 1.6X10-5 atm-cu m/mole(SRC), developed using a fragment constant estimation method(2). Using this Henry's Law constant and an estimation method(3), volatilization half-lives for a model river and model lake are 2.5 and 21 days, respectively(SRC). According to a classification scheme(4), an estimated BCF of 5(SRC), from an estimated log Kow of 1.61(2) and a regression-derived equation(2), suggests the potential for bioconcentration in aquatic organisms is low(SRC). An 87% of theoretical BOD using activated sludge in the Japanese MITI test(5) suggests that biodegradation is an important environmental fate process in water(SRC). cis-3-Hexen-1-ol is not expected to undergo hydrolysis in the environment due to the lack of functional groups that hydrolyze under environmental conditions(3). cis-3-Hexen-1-ol is an olefin and olefins in surface waters exposed to sunlight react with photo-oxidants (such as hydroxyl radicals, peroxy radicals and singlet oxygen) with a half-life on the order of 25 days reported(6).

ATMOSPHERIC FATE: According to a model of gas/particle partitioning of semivolatile organic compounds in the atmosphere(1), cis-3-hexen-1-ol, which has an estimated vapor pressure of 0.94 mm Hg at 25 °C(SRC), determined from a fragment constant method(2), is expected to exist solely as a vapor in the ambient atmosphere. Vapor-phase cis-3-hexen-1-ol is degraded in the atmosphere by reaction with photochemically-produced hydroxyl radicals(SRC); the half-life for this reaction in air is estimated to be 3.6 hours(SRC), calculated from its rate constant of 1.06X10-10 cu cm/molecule-sec at 24 °C(3). cis-3-Hexen-1-ol is also degraded in the atmosphere by reaction with ozone, nitrate radicals and direct photolysis(4). The half-life for the reaction with ozone is estimated to be 7.5 hours(SRC), calculated from its rate constant of 3.69X10-17 cu cm/molecule-sec at 25 °C(5). The half-life for the reaction with nitrate radicals is estimated to be 2.1 hours(SRC), calculated from its rate constant of 2.67X10-13 cu cm/molecule-sec at 25 °C(5). The nitrate radical (NO3) is the dominant atmospheric oxidant during the night-time in most atmospheric environments(6), therefore, night-time degradation appears to be a major fate process for cis-3-hexen-1-ol(SRC). cis-3-Hexen-1-ol absorbs at wavelengths >290 nm(4), and a calculated upper limit direct photolysis rate constant at ground level of 1.61X10-5/sec(4) corresponds to a half-life of about 12 hours(SRC).

cis-3-Hexen-1-ol has been detected in the skin and pulp of Queen Anne's pocket melon (Cucumus melo var. dudaim L.) at concentrations of 37.6 and 6.9 ug/kg respectively(1). cis-3-Hexen-1-ol was identified in the volatile components of ripe and very ripe kiwi fruit (Actinidia chinensis) at levels of 0.1-0.2% of the total amount(2). Analysis of the volatile components of pineapple guava (Feihoa sellowiana) detected cis-3-hexen-1-ol(3). cis-3-Hexen-1-ol was detected in canned cream corn and canned kernel corn at respective concentrations of 1 and 2 ppb(4); concentrations in fresh and frozen kernel corn was <1 ppb(4). cis-3-Hexen-1-ol was detected in the volatile compounds from edible Korean Chamchwi (Aster scaber Thunb)(5). Concentration of cis-3-hexen-1-ol in mature and overripe guava fruit (Psidium guajava L.) was 8736.9 and 2630.6 ug/kg, respectively(6). Nectarines (Prunus persica L.) were found to contain cis-3-hexen-1-ol at concentrations of 30-110 ug/kg(7). Analysis of the volatile compounds in plums (Prunus salicina Lindl.) detected cis-3-hexen-1-ol at 13 ug/kg(8). cis-3-Hexen-1-ol was detected in Japanese muskmelon (Cucumis melo L.)(9), in stored mango(10) and in kiwi fruit flowers(11). cis-3-Hexen-1-ol was detected in a variety of honeydew melons at mean concentrations of 22.3-33.5 ug/kg(12). cis-3-Hexen-1-ol is reported to occur in over 200 foods including apple, banana, apricot, citrus, berries, grapes, pineapple, cabbage, celery, peas, tomato, butter and many others(13).

IDENTIFICATION AND USE: 3-Hexenol is a colorless liquid. It has a strong, fresh-cut grass odor and a fresh green, fruity taste. It is released to the air from a variety of plants including grass, clover, alfalfa, grapes, onions, peaches and oak trees. It is present in the green parts of nearly all plants. It is reported to be found in several essential oils and in many fruit juices and is a component of tobacco smoke. 3-Hexenol is used as a fragrance in perfumes, household cleaners, and food flavoring. HUMAN EXPOSURE AND TOXICITY: Tested at 4% in petrolatum, 3-hexenol produced no irritation after a 48 hour closed patch test in humans. Odorization of inert gas can serve to warn workers in an enclosed space. A psychophysical investigation examined 3-hexenol as a candidate for the possible odorization of argon. The detection threshold for 3-hexenol in argon was 19 ppb. 3-Hexenol did not induce any statistically significant increases in the frequency of human lymphocytes with chromosome aberrations in either the absence or presence of a liver enzyme metabolizing system. ANIMAL STUDIES: The LD50 of 3-hexenol in rats and mice was in the range of 7-10 g/kg by the oral route and 0.4-0.6 g/kg by the intraperitoneal route. No effects were seen at 310 and 1250 ppm, but in males of the 5000-ppm group the intake of drinking water was reduced compared with controls, the relative kidney weight was increased and the urine collected in the first 2 hr after a water load was more concentrated. In females, the only finding was a transitory anemia at this level. In another study, 3-hexanol applied at full strength to rabbit skin for 24 hours produced no irritation. In rats, an analysis of Fos protein was performed as a way of investigating the effects of inhalation of green odor (a mixture of of trans-2-hexenal and 3-hexenol) on the neuronal activations in stress-related forebrain regions induced by acute and repeated stress. Green odor had inhibitory effects on the stress-induced corticosterone response, body-weight loss, and adrenal hypertrophy. In another study, the reproductive toxicity via the oral route was assessed in rats at dose levels of 100, 300 and 1000 mg/kg/day. Based on the results of the study, a NOAEL for general toxicity in males and females was considered to be 1000 mg/kg/day, the highest dose level tested. The potential mutagenicity of 3-hexenol on the thymidine kinase, TK +/-, locus of the L5178Y mouse lymphoma cell line was assessed. 3-Hexenol did not induce any toxicologically significant increases in the mutant frequency at the TK +/- locus in L5178Y cells and is therefore considered to be non-mutagenic under the conditions of the test.

Robinia pseudacacia /black locust; Fabaceae/ and mulberry /Morus sp.; Moraceae/ leaf oil contain up to 50% cis-3-hexen-1-ol, and green tea contains up to 30%(1); small quantities occur in the green parts of nearly all plants(1).

cis-3-Hexen-1-ol detections in plants(1).[Table#8254]

cis-3-Hexen-1-ol has been detected in volatile emissions from biodegradable household waste and industrial building materials(1). cis-3-Hexen-1-ol is a biogenic volatile compound emitted into the atmosphere globally from a wide range of plants including grass, clover, alfalfa, grape, lettuce, onion, orange, peach and oak(2). cis-3-Hexen-1-ol was identified as a volatile emission product from agricultural and natural plant types found in California's Central Valley(3). Leaves of the Eucalyptus dunni trees were found to emit cis-3-hexen-1-ol(4).

Using a structure estimation method based on molecular connectivity indices(1), the Koc of cis-3-hexen-1-ol can be estimated to be 12(SRC). According to a classification scheme(2), this estimated Koc value suggests that cis-3-hexen-1-ol is expected to have very high mobility in soil.

cis-3-Hexen-1-ol is a biogenic volatile compound emitted into the atmosphere globally from a wide range of plants including grass, clover, alfalfa, grape, lettuce, onion, orange, peach and oak(1). cis-3-Hexen-1-ol occurs in the leaves of odoriferous plants including shrubs and trees(2). Small quantities occur in the green parts of nearly all plants(3).

Herbivore attack is known to increase the emission of volatiles, which attract predators to herbivore-damaged plants in the laboratory and agricultural systems. We quantified volatile emissions from Nicotiana attenuata plants growing in natural populations during attack by three species of leaf-feeding herbivores and mimicked the release of five commonly emitted volatiles individually. Three compounds (cis-3-hexen-1-ol, linalool, and cis-alpha-bergamotene) increased egg predation rates by a generalist predator; linalool and the complete blend decreased lepidopteran oviposition rates. As a consequence, a plant could reduce the number of herbivores by more than 90% by releasing volatiles. These results confirm that indirect defenses can operate in nature.

/HUMAN EXPOSURE STUDIES/ Tested at 4% in petrolatum, cis-3-Hexenol produced no irritation after a 48 hour closed patch test in human subjects.

/GENOTOXICITY/ The cytogenicity potential of /cis-hex-3-en-ol/ was assessed according to OECD guideline 473. The test item did not induce any statistically significant increases in the frequency of cells with chromosome aberrations in either the absence or presence of a liver enzyme metabolising system in either of the 2 separate experiments. The test item was therefore considered to be non-clastogenic to human lymphocytes in vitro.

/OTHER TOXICITY INFORMATION/ Odorization of inert gas can serve to warn workers in an enclosed space about gas leaking into the space. This psychophysical investigation, performed under conditions of directed attention, examined two candidates for possible odorization of argon:pyridine and cis-3-hexen-1-ol. Detection thresholds for pyridine and cis-3-hexen-1-ol in argon were 106 ppb and 19 ppb, respectively. Practice over four days yielded modest improvement in the detection of both odorants. For cis-3-hexen-1-ol, smokers had marginally lower thresholds than nonsmokers and older participants had slightly higher thresholds than younger participants. Gender, smoking status and age had no reliable influence on threshold for pyridine. This outcome indicated desirable perceptual stability for pyridine. Additional experiments dealt with the perceived intensity of pyridine and cis-3-hexen-1-ol over time in the realistic setting of an environmental chamber. Visitors to the chamber and occupants in the chamber assessed perceived magnitude at 5-min intervals for up to 60 min during injections of odorized argon into the chamber. Participants could gauge and track the concentration of pyridine much better than that of cis-3-hexen-1-ol. This held true for occupants almost to the same degree as visitors, though occupants inevitably exhibited some olfactory adaptation. Hence, the suprathreshold measurements also gave strong relative endorsement to pyridine. Calculations based on the experimental results indicated that odorization of the inert gas stream with 3 to 10 ppm (v/v) pyridine should suffice to warn occupants or visitors of an argon buildup of any severity. Field studies should permit a definitive judgment of the best concentration to use in practice.

3-Hexen-1-ol is a food additive permitted for direct addition to food for human consumption as a synthetic flavoring substance and adjuvant in accordance with the following conditions: a) they are used in the minimum quantity required to produce their intended effect, and otherwise in accordance with all the principles of good manufacturing practice, and b) they consist of one or more of the following, used alone or in combination with flavoring substances and adjuvants generally recognized as safe in food, prior-sanctioned for such use, or regulated by an appropriate section in this part.

Residues of 3-hexen-1-ol, (3Z)- are exempted from the requirement of a tolerance when used in accordance with good agricultural practice as inert (or occasionally active) ingredients in pesticide formulations applied to growing crops or to raw agricultural commodities after harvest. Use: Odorant, alerting agent. Limit: Not more than 0.4% of the pesticide formulation.

Residues of the following chemical substances are exempted from the requirement of a tolerance when used in accordance with good manufacturing practice as ingredients in an antimicrobial pesticide formulation, provided that the substance is applied on a semi-permanent or permanent food-contact surface (other than being applied on food packaging) with adequate draining before contact with food. (a) The following chemical substances when used as ingredients in an antimicrobial pesticide formulation may be applied to: Food-contact surfaces in public eating places, dairy-processing equipment, and food-processing equipment and utensils. (Z)-3-Hexenol is included on this list. Limit: When ready for use, the end-use concentration is not to exceed 100 ppm.