Water → cis-3-(3-(3-Hexenyloxy)-1,2,5-thiadiazol-4-yl)pyridine
反応式
[CH2:1]([OH:7])[CH2:2]/[CH:3]=[CH:4]\[CH2:5][CH3:6].[H-].[Na+].Cl[C:11]1[C:12]([C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)=[N:13][S:14][N:15]=1.O>O1CCCC1>[CH2:1]([O:7][C:11]1[C:12]([C:16]2[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=2)=[N:13][S:14][N:15]=1)[CH2:2]/[CH:3]=[CH:4]\[CH2:5][CH3:6]参加物
6
実験手順
To a solution of cis-3-hexen-1-ol (900 mg, 9 mmol) and sodium hydride (310 mg, 9 mmol) in dry tetrahydrofuran was added a solution of 3-(4-chloro-1,2,5-thiadiazol-3-yl) pyridine (590 mg, 3 mmol) in dry tetrahydrofuran. The reaction mixture was stirred at room temperature for 1 h. Water was added and the mixture was extracted with ether. The ether phase was dried and evaporated to give the title compound.
後処理
- extractionthe mixture was extracted with ether
- dry with materialThe ether phase was dried
- customevaporated
出典と根拠
- ORDレコード
- ord-fb3525c057624917a66ebbf8224cc6aa
- 出典データセット
- uspto-grants-1998_01
- 特許番号
- US05712297
反応ノート
読み込み中…