Hydrochloric Acid → 2-Ethoxy-4-aminobenzoic acid

HRID 1352657

反応式

HRID 1352657 の反応式
[CH2:1]([O:3][C:4]1[CH:13]=[C:12]([NH:14]C(=O)C)[CH:11]=[CH:10][C:5]=1[C:6]([O:8]C)=[O:7])[CH3:2].Cl>[OH-].[Na+]>[CH2:1]([O:3][C:4]1[CH:13]=[C:12]([NH2:14])[CH:11]=[CH:10][C:5]=1[C:6]([OH:8])=[O:7])[CH3:2]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 6034Ethopabate

生成物 1

HCID 101763852-Ethoxy-4-aminobenzoic acid収率 100.2%

試薬・触媒・溶媒 1

HCID 14798Sodium Hydroxide溶媒

実験手順

A suspension of methyl 2-ethoxy-4-acetamidobenzoate (50 g, 211 mmol) in aqueous solution of NaOH (15% W/W, 200 ml) was gently refluxed for 16 hours. The resulting pale brown solution was allowed to cool to room temperature and then further cooled in an ice water bath. Concentrated HCl (37% w/w) was added until the solution reached a pH of 6. The solid precipitated from the solution was filtered under vacuum, dried at 50° C. to give 38.3 g of the title compound (yield 100%).

後処理

  1. temperaturewas gently refluxed for 16 hours
  2. temperaturefurther cooled in an ice water bath
  3. customThe solid precipitated from the solution
  4. filtrationwas filtered under vacuum
  5. customdried at 50° C.

出典と根拠

ORDレコード
ord-f89630faf6d341dabf6823615714d1c1
出典データセット
uspto-grants-2007_05
特許番号
US07220769B2

関連ノート

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