Trisodium citrate

Metals -> Organic Acids, Metal Salts

Metals -> Organic Acids, Metal Salts

Cosmetic ingredients (Sodium Citrate) -> CIR (Cosmetic Ingredient Review)

Buffering; Chelating

COLOR OR COLORING ADJUNCT, EMULSIFIER OR EMULSIFIER SALT, FLAVORING AGENT OR ADJUVANT, MALTING OR FERMENTING AID, NUTRIENT SUPPLEMENT, PH CONTROL AGENT, SEQUESTRANT, STABILIZER OR THICKENER, SURFACE-ACTIVE AGENT -> FDA Substance added to food

29.4g/L

White, odorless crystals, granules or powder; cool, saline taste. Stable in air; becomes anhydrous at 150 °C. Sol in 1.3 parts water, 0.6 part boiling water. Insol in alcohol. The aqueous soln is slightly alkaline to litmus; pH about 8; /Dihydrate/

Solubility in water, g/100ml at 25 °C: 42.5

FDA approved drugs -> Active ingredient

FDA approved drugs -> Active ingredient

CBI; Large Crystals; Other Solid; Dry Powder; Liquid

Crystalline white powder or colourless crystals

White solid; [ICSC]

White odorless solid; [JECFA] White crystalline powder; [Alfa Aesar MSDS]

WHITE GRANULES OR POWDER.

This chemical does not meet GHS hazard criteria for 94.3% (1117 of 1184) of all reports.

Not Classified

Aggregated GHS information provided per 1184 reports by companies from 9 notifications to the ECHA C&L Inventory.

This chemical does not meet GHS hazard criteria for 27.7% (41 of 148) of reports.

Warning

H319 (72.3%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]

Chemical: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt

Chemical: 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt (1:3) is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt (1:3) are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

Status: Active Update: 02-05-2023 https://echa.europa.eu/registration-dossier/-/registered-dossier/15303

Trisodium citrate: Does not have an individual approval but may be used under an appropriate group standard

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt: Does not have an individual approval but may be used as a component in a product covered by a group standard. It is not approved for use as a chemical in its own right.

IMAP assessments - 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt: Environment tier I assessment

IMAP assessments - 1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt: Human health tier I assessment

Emergency treatment: symptomatic drug ingestion; [HSDB] An eye and respiratory tract irritant; [ICSC] May cause irritation; [MSDSonline] See Citric acid.

Causes convulsions in intraperitoneal lethal-dose studies of mice and rats; [RTECS] Acceptable daily intake (ADI) as food additive not limited; [JECFA] May cause irritation; [Alfa Aesar MSDS] See Citric acid.

Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).

Trisodium citrate is a prior sanctioned food ingredient classified as a stabilizer when migrating from food-packaging material.

Chemical: Sodium citrate, anhydrous

Chemical: Sodium citrate

Eye Irrit. 2 (72.3%)

Not Classified

Not Classified

Fresh air, rest.

Rinse and then wash skin with water and soap.

First rinse with plenty of water for several minutes (remove contact lenses if easily possible), then refer for medical attention.

Rinse mouth.

SRP: At the time of review, criteria for land treatment or burial (sanitary landfill) disposal practices are subject to significant revision. Prior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agencies for guidance on acceptable disposal practices.

9.0 [mg/m3]

99 [mg/m3]

590 [mg/m3]

9.3 [mg/m3]

100 [mg/m3]

610 [mg/m3]

Cough. Sore throat.

Redness.

Manufacturers, packers, and distributors of drug and drug products for human use are responsible for complying with the labeling, certification, and usage requirements as prescribed by the Federal Food, Drug, and Cosmetic Act, as amended (secs 201-902, 52 Stat. 1040 et seq., as amended; 21 U.S.C. 321-392).

Trisodium citrate is a prior sanctioned food ingredient classified as a stabilizer when migrating from food-packaging material.

B - Blood and blood forming organs

QB - Blood and blood forming organs

Citrate chelates free calcium ions preventing them from forming a complex with tissue factor and coagulation factor VIIa to promote the activation of coagulation factor X. This inhibits the extrinsic initiation of the coagulation cascade. Citrate may also exert an anticoagulant effect via a so far unknown mechanism as restoration of calcium concentration does not fully reverse the effect of citrate. Citrate is a weak base and so reacts with hydrochloric acid in the stomach to raise the pH. It it further metabolized to bicarbonate which then acts as a systemic alkalizing agent, raising the pH of the blood and urine. It also acts as a diuretic and increases the urinary excretion of calcium.

Citrate is metabolized to bicarbonate in the liver and plays a role as an intermediate in the citric acid cycle.

IN THE BODY, SODIUM CITRATE IS OXIDIZED TO BICARBONATE...

SODIUM CITRATE

Anti-coagulant [EPC]; Acidifying Activity [MoA]; Decreased Coagulation Factor Activity [PE]; Calcium Chelating Activity [MoA]; Calculi Dissolution Agent [EPC]

Agents that prevent BLOOD CLOTTING.

A chemical system that functions to control the levels of specific ions in solution. When the level of hydrogen ion in solution is controlled the system is called a pH buffer.

Substances capable of inhibiting, retarding or arresting the process of fermentation, acidification or other deterioration of foods.

Tmax of 98-130min.

Largely eliminated through hepatic metabolism with very little cleared by the kidneys.

19-39L.

Total clearance of 313-1107mL/min.

IN THE BODY, SODIUM CITRATE IS OXIDIZED TO BICARBONATE & EXCRETED IN THE URINE...

CIR ingredient: Sodium Citrate

Used as an emulsifier, acidulant, sequestrant, medication (expectorant, systemic alkalizer, diuretic, sudorific, and anticoagulant), and general purpose additive for foods; Also used in photography, detergents, and electroplating and to remove sulfur dioxide from smelter waste gases; [HSDB]

Electroplating [Category: Plate]

Used as a buffering agent and sequestrant for food; [JECFA] Permitted for use as an inert ingredient in non-food pesticide products; [EPA]

AS A PHARMACEUTIC AID, SODIUM CITRATE IS USED TO PREVENT DARKENING WHEN IRON IS ADDED TO PREPARATIONS CONTAINING TANNIN.

OFFICIALLY RECOGNIZED ONLY FOR ITS USE AS A BLOOD ANTICOAGULANT FOR BLOOD OR PLASMA THAT IS TO BE FRACTIONATED OR FOR BLOOD THAT IS TO BE STORED. THE ANTICOAGULANT EFFECT IS DUE TO THE CONVERSION OF IONIZED CALCIUM IN THE BLOOD TO NONIONIZED CALCIUM CITRATE.

USUALLY BY ADDING SODIUM CARBONATE TO A SOLN OF CITRIC ACID UNTIL EFFERVESCENCE CEASES, EVAPORATING, AND GRANULATING THE PRODUCT.

Sodium sulfate soln is treated with calcium citrate, filtered, concentrated and crystallized. /Dihydrate/

SODIUM CITRATE IS AN INGREDIENT IN ANTICOAGULANT CITRATE DEXTROSE SOLUTION USP; ANTICOAGULANT CITRATE PHOSPHATE DEXTROSE SOLUTION USP; & SODIUM CITRATE & CITRIC ACID SOLUTION USP.

Grades: highest purity, medicinal; pure, commercial, CP; USP; FCC. /Dihydrate/

Information on 532 consumer products that contain Sodium citrate (Trisodium citrate) in the following categories is provided:

Information on 54 consumer products that contain Sodium Citrate in the following categories is provided:

EPA Safer Chemical Functional Use Classes -> Chelating Agents;Preservatives and Antioxidants;Processing Aids and Additives

Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern

EPA Safer Chemical Functional Use Classes -> Chelating Agents;Preservatives and Antioxidants;Processing Aids and Additives

Safer Chemical Classes -> Green circle - The chemical has been verified to be of low concern

Food additives

Fragrance Ingredients

Soap, Cleaning Compound, and Toilet Preparation Manufacturing

1,2,3-Propanetricarboxylic acid, 2-hydroxy-, sodium salt (1:3): ACTIVE