Glycolide (HCID 65432)

概要

ABH001 is under investigation in clinical trial NCT01749306 (A Study of the Efficacy and Safety of ABH001 in the Treatment of Patients With Epidermolysis Bullosa Who Have Wounds That Are Not Healing).

名称と識別子

優先名称: Glycolide
IUPAC: 1,4-dioxane-2,5-dione
現地名: 1,4-ジオキサン-2,5-ジオン
英語名: 1,4-Dioxane-2,5-dione
分子式: C4H4O4
分子量: 116.07

名称と別名

GlycolideGlycollidep-Dioxane-2,5-dioneUNII-YRZ676PGU6YRZ676PGU6EINECS 207-954-9NSC 403079NSC-403079RefChem:74901,4-Dioxane-2,5-dione502-97-6MFCD00081108

名称をさらに表示

ジグリコリドグリコリド1,4-ジオキサン-2,5-ジオン1,4‐ジオキサン‐2,5‐ジオングリコリド, 99.9%GlycolidGLYCOLIDE A1,4-DIOXANE-2,3-DIOLL10014EGlycolide>GLYCOLIDE USPPURASORB(R) GGA Glycolide

1,4-Dioxan-2,5-dioneGlycolide S;Glycollide; Glycolide26202-08-42,5-dioxo-1,4-dioxaneGlycolide,99.9%Glycolide, >=99%SCHEMBL15066ABH001

データベース識別子

CAS: 502-97-6
PubChem CID: 65432
DTXSID: DTXSID8060115
UNII: YRZ676PGU6
EC Number: 207-954-9
Nikkaji: J2.602F

物性

構造計算による物性

XLogP: -0.2
極性表面積: 52.6 Å²
水素結合供与体数: 0
水素結合受容体数: 4
回転可能結合数: 0
重原子数: 8
形式電荷: 0
複雑度: 112

実験および物理化学的性質

SpringerMaterials PropertiesFusion temperature

Physical DescriptionLarge Crystals

物理化学的性質

融点: 81 · 81-83°C
沸点: 130 °C · 130°C(lit.)
比重(密度): 1.1315 · 1.1315 (rough estimate)
屈折率: 1.45 · 1.4500 (estimate)
貯蔵温度: -20 °C · -20°C
溶解性: ジクロロメタン（微量）、DMSO（微量）
外見: 個体
色: ホワイトからオフホワイト
安定性: Hygroscopic
化粧品成分の機能: 保湿剤スキンコンディショニング
InChI: InChI=1S/C4H4O4/c5-3-1-7-4(6)2-8-3/h1-2H2
InChIKey: RKDVKSZUMVYZHH-UHFFFAOYSA-N
SMILES: O1CC(=O)OCC1=O
CAS データベース: 502 · 502-97-6(CAS DataBase Reference)
NISTの化学物質情報: 1 · 1,4-Dioxane-2,5-dione(502-97-6)
EPAの化学物質情報: 1 · 1,4-Dioxane-2,5-dione (502-97-6)

化学的性質

化学的特性mp 82-86°C 99.5+%

安全と法規制

GHS分類

GHS Classification · 4 件

Warning

H302 (93.3%): Harmful if swallowed [Warning Acute toxicity, oral]

P264, P264+P265, P270, P280, P301+P317, P305+P351+P338, P330, P337+P317, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 45 reports by companies from 4 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory Information · 3 件

1,4-Dioxane-2,5-dione is listed on the EPA's Chemical Data Reporting (CDR) system. Manufacturers and importers of 1,4-Dioxane-2,5-dione are required to report information about their production and use of this chemical to the EPA under the Toxic Substances Control Act (TSCA). (40 eCFR Part 711)

PMN - indicates a commenced PMN (Pre-Manufacture Notices) substance.

Status: Active Update: 08-07-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/20813

Hazard Classes and CategoriesAcute Tox. 4 (93.3%)

安全データ

wgk: 3
tsca: TSCA listed
hs_code: 29322090
risk_code: 36/37/38-36-22
化審法: (5)-6815, (5)-6865
hazard_code: Xi,Xn
safety_code: 22-24/25-37/39-26
Hazard Classifications: Acute Tox. 4 OralEye Irrit. 2
ストレージクラス: 11 - Combustible Solids

化学と産業

用途と製造

U.S. Production2020: 442,847 lb

Industry UsesMonomers

General Manufacturing Information · 2 件

Plastics Material and Resin Manufacturing

1,4-Dioxane-2,5-dione: ACTIVE

応用分野 · 3 件

解説グリコリド，グリコール酸のラクチドをいう．グリコール酸を真空蒸留するか，無水酢酸と煮沸後蒸留すると得られる．うろこ状結晶．融点84 ℃，沸点240～241 ℃．アセトン，熱エタノールおよびクロロホルムに易溶．刺激性がある.

使用1,4-Dioxane-2,5-dione is used in the fabricating of artificial blood vessels.

一般的な説明Glycolide is a cyclic dimer of α-hydroxy acid that can be used in the formation of aliphatic polyester. It is synthesized by the dimerization of glycolic acid. It forms a low toxic synthetic biodegradable polymer that can be used in medical applications. It is majorly used in the formation of a highly crystalline poly(glycolide) by ring opening polymerization.