Mops (HCID 70807)｜化工社

名称と識別子

優先名称: Mops
IUPAC: 3-morpholin-4-ylpropane-1-sulfonic acid
現地名: 3-モルホリノプロパンスルホン酸
英語名: MOPS
分子式: C7H15NO4S
分子量: 209.26

名称と別名

MOPS1132-61-23-Morpholinopropanesulfonic acid4-Morpholinepropanesulfonic acid3-(N-Morpholino)propanesulfonic acidMorpholinopropane sulfonic acid3-morpholin-4-ylpropane-1-sulfonic acidMorpholinopropanesulfonic acidDTXSID4044371273BP63NV3DTXCID2024371CHEBI:44115

名称をさらに表示

3-モルホリノプロパンスルホン酸4-モルホリンプロパン-1-スルホン酸3-モルホリノプロパン-1-スルホン酸3-モルホリノ-1-プロパンスルホン酸3-(4-モルホリニル)-1-プロパンスルホン酸3-N-モルホリノプロパンスルホン酸3-（4-モルホリノ）プロパンスルホン酸3‐モルホリノプロパンスルホン酸モプス3-(N-モルホリノ)プロパンスルホン酸(MOPS)MOPS, 結晶, フリー酸MOPS, 分子生物学用MOPS, 1M緩衝液3-(モルホリノ)-1-プロパンスルホン酸3-(モルホリン-4-イル)プロパン-1-スルホン酸3-(モルホリノ)プロパン-1-スルホン酸MPSMOPS FREE ACID4-propanesulfonyl morpholine3-Morpholinopropanesulfoinc Acid4-morpholinopropanesulphonic acid3-MORPHOLINOPROPANESULPHONIC ACID

RefChem:926116morpholine propanesulphonic acidCHEBI:39074214-478-53-Morpholinopropane-1-sulfonic acid3-(morpholin-4-yl)propane-1-sulfonic acid3[N-MORPHOLINO]PROPANE SULFONIC ACIDMFCD00006183

データベース識別子

CAS: 1132-61-2
PubChem CID: 70807
DTXSID: DTXSID4044371
ChEMBL: CHEMBL1234443
ChEBI: CHEBI:44115
UNII: 273BP63NV3
EC Number: 214-478-5
Nikkaji: J7.270B

物性

構造計算による物性

XLogP: -3.1
極性表面積: 75.2 Å²
水素結合供与体数: 1
水素結合受容体数: 5
回転可能結合数: 4
重原子数: 13
形式電荷: 0
複雑度: 227

実験および物理化学的性質

Physical DescriptionWhite solid; [Merck Index] White odorless powder; [Caledon Laboratories MSDS]

Collision Cross Section · 1 件

142.7 Å² [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: APCI+; Dataset: TOXCAST; Source Identifier: DTXSID4044371]；149.5 Å² [M-H]- [CCS Type: DT; Buffer gas: N2; Ionization: ESI-; Dataset: TOXCAST; Source Identifier: DTXSID4044371]；154.6 Å² [M+Na]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID4044371]；142.4 Å² [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: ESI+; Dataset: TOXCAST; Source Identifier: DTXSID4044371]

物理化学的性質

融点: 277 · 277-282 °C
比重(密度): 1.3168 · 1.3168 (rough estimate)
蒸気圧: 0 Pa · 0Pa at 25℃
屈折率: 1.637 · 1.6370 (estimate)
闪点: 116 °C · 116 °C
貯蔵温度: room temp
溶解性: 2 O: · H2O: 1M at20℃、透明
外見: 粉体・固形
色: 白い
PH: 2.5 · 2.5-4.0 (25℃, 1M in H2O)
酸解離定数(Pka): 7.2 · 7.2(at 25℃)
臭い (Odor): 無臭
由来生物: synthetic
水溶解度: 1000 g/L · 1000g/L（20℃）
Merck: 14 · 14,6265
BRN: 1106776 · 1106776
安定性: 安定。強塩基、強酸化剤とは相容れない。
化粧品成分の機能: バッファリング漂白
InChI: 1S/C7H15NO4S/c9-13(10,11)7-1-2-8-3-5-12-6-4-8/h1-7H2,(H,9,10,11)
InChIKey: DVLFYONBTKHTER-UHFFFAOYSA-N
SMILES: OS(=O)(=O)CCCN1CCOCC1
LogP: -2.94 at · -2.94 at 20℃
CAS データベース: 1132 · 1132-61-2(CAS DataBase Reference)
EPAの化学物質情報: 4 · 4-Morpholinepropanesulfonic acid (1132-61-2)
Absorption: 0.05 at · ≤0.05 at 260nm≤0.05 at 280nm

化学的性質

化学的特性White/clear crystalline powder

安全と法規制

GHS分類

GHS Classification · 6 件

This chemical does not meet GHS hazard criteria for 45.9% (189 of 412) of reports.

Warning

H315 (53.4%): Causes skin irritation [Warning Skin corrosion/irritation]；H319 (53.4%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]；H335 (52.7%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

P261, P264, P264+P265, P271, P280, P302+P352, P304+P340, P305+P351+P338, P319, P321, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 412 reports by companies from 18 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.；Reported as not meeting GHS hazard criteria per 189 of 412 reports by companies.；There are 16 notifications provided by 223 of 412 reports by companies with hazard statement code(s).；Information may vary between notifications depending on impurities, additives, and other factors. The percentage value in parenthesis indicates the notified classification ratio from companies that provide hazard codes. Only hazard codes with percentage values above 10% are shown. For more detailed information, please visit ECHA C&L website.

危険有害性情報

Regulatory Information · 3 件

Chemical: 4-Morpholinepropanesulfonic acid

Status: Active Update: 06-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/21270；Status: Active Update: 09-11-2017 https://echa.europa.eu/registration-dossier/-/registered-dossier/21115

MOPS: Does not have an individual approval but may be used under an appropriate group standard

Hazards SummaryMay cause irritation; [Caledon Laboratories MSDS] See N-Ethylmorpholine.

Hazard Classes and CategoriesSkin Irrit. 2 (53.4%)；Eye Irrit. 2 (53.4%)；STOT SE 3 (52.7%)

法規制情報

Regulatory Information · 3 件

Chemical: 4-Morpholinepropanesulfonic acid

Status: Active Update: 06-12-2022 https://echa.europa.eu/registration-dossier/-/registered-dossier/21270；Status: Active Update: 09-11-2017 https://echa.europa.eu/registration-dossier/-/registered-dossier/21115

MOPS: Does not have an individual approval but may be used under an appropriate group standard

安全データ

wgk: 1
tsca: TSCA listed
rtecs: QE9104530
hs_code: 29349990
risk_code: 36/37/38
hazard_code: Xi
safety_code: 26-36
ストレージクラス: 11 - Combustible Solids

化学と産業

用途と製造

UsesUsed as a biological buffer; [Merck Index] Used as a laboratory reagent; [Caledon Laboratories MSDS]

General Manufacturing Information4-Morpholinepropanesulfonic acid: ACTIVE

応用分野 · 3 件

用途MOPS（3-モルホリノプロパンスルホン酸、英：3-(N-morpholino)propanesulfonic acid）は、緩衝剤として利用される有機化合物の一つ。生化学分野で広く用いられる。 20℃においてのpKaは6.15であり、溶液はpH 6.5～7.9および0.02～1 Mの範囲で緩衝液として機能する。 MOPSはポリアクリルアミドゲル電気泳動（PAGE）のバッファーとして推奨されている。哺乳類細胞株の培養に20 mM以上のMOPSは適していない。

使用Due to its inert nature, 3-morpholinopropanesulfonic acid (MOPS) is widely used as a buffer in many biochemical studies. MOPS has been used as a cell culture additive component in lentiviral particle production, a buffering agent in microbial growth medium and nuclei extraction buffer, a component of Roswell Park Memorial Institute (RPMI) medium for diluting fungal inoculum, and a buffer in capillary-zone electrophoresis to test performance. It is also used for the dilution of proteins from algal samples.

一般的な説明3-(N-Morpholino)propane sulfonic acid (MOPS) is an N-substituted amino sulfonic acid with a morpholinic ring. MOPS is capable of buffering within a pH range of 6.5-7.9. MOPS is widely used in biological and biochemical studies due to its inert properties. It does not interact with any metal ions in solutions and has significant metal-buffer stability especially with copper (Cu), nickel (Ni), manganese (Mn), zinc (Zn), cobalt (Co) ions. MOPS buffer maintains the pH of the mammalian cell culture medium. MOPS functions to maintain pH in denaturing gel electrophoresis of RNA. MOPS can modify lipid interactions and influence the thickness and barrier properties of membranes. MOPS interacts with bovine serum albumin and stabilizes the protein. Hydrogen peroxide oxidizes MOPS slowly to N-oxide form.

上流・下流製品情報

上流原料

プロパンスルトン

サプライヤー50 社

国药集团化学试剂有限公司86-21-63210123 · [email protected]

北京华美互利生物化工010-56205725 · [email protected]

梯希爱(上海)化成工业发展有限公司021-67121386 · [email protected]

上海阿拉丁生化科技股份有限公司400-6206333 13167063860 · [email protected]

武汉德晟生化科技有限公司0711-3702650 18971041571 · [email protected]

補足説明 · 1 件

定義ChEBI: 3-(N-morpholino)propanesulfonic acid is a Good's buffer substance, pKa = 7.2 at 20 ℃. It is a member of morpholines, a MOPS and an organosulfonic acid. It is a conjugate acid of a 3-(N-morpholino)propanesulfonate. It is a tautomer of a 3-(N-morpholiniumyl)propanesulfonate.