Thionyl Chloride → 3-(Morpholin-4-yl)propane-1-sulfonyl chloride hydrochloride

HRID 323999

反応式

HRID 323999 の反応式
S(Cl)([Cl:3])=O.[N:5]1([CH2:11][CH2:12][CH2:13][S:14]([OH:17])(=O)=[O:15])[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1>CN(C)C=O>[ClH:3].[N:5]1([CH2:11][CH2:12][CH2:13][S:14]([Cl:3])(=[O:17])=[O:15])[CH2:10][CH2:9][O:8][CH2:7][CH2:6]1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 70807Mops

生成物 1

HCID 220077423-(Morpholin-4-yl)propane-1-sulfonyl chloride hydrochloride

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

Thionyl chloride (10 ml) was added to 4-morpholinepropane sulfonic acid (4.4 g) followed by dimethylformamide (0.2 ml). The mixture was heated at reflux under nitrogen for 5 h. The thionyl chloride was removed in vacuo and the residue triturated with acetonitrile and filtered to give a white solid. This was dried at 80° C. in vacuo to give the title compound as a white solid (2.7 g). Found: C,31.9; H,5.9; N,5.1. C7H14CINO3S.HCl requires C,31.8; H,5.7; N,5.3%.

後処理

  1. temperatureThe mixture was heated
  2. temperatureat reflux under nitrogen for 5 h
  3. customThe thionyl chloride was removed in vacuo
  4. customthe residue triturated with acetonitrile
  5. filtrationfiltered
  6. customto give a white solid
  7. customThis was dried at 80° C. in vacuo

出典と根拠

ORDレコード
ord-92545e80488c437e82342ec16f9d052a
出典データセット
uspto-grants-2001_04
特許番号
US06215002B1

関連ノート

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