Ethyl chloroformate → Ethyl 2,2-dimethoxyethylcarbamate

HRID 36663

反応式

HRID 36663 の反応式
Cl[C:2]([O:4][CH2:5][CH3:6])=[O:3].[CH3:7][O:8][CH:9]([O:12][CH3:13])[CH2:10][NH2:11].[OH-].[Na+]>C1(C)C=CC=CC=1.O>[CH3:7][O:8][CH:9]([O:12][CH3:13])[CH2:10][NH:11][C:2](=[O:3])[O:4][CH2:5][CH3:6]

参加物

6

反応物 3

HCID 10928Ethyl chloroformateHCID 14798Sodium HydroxideHCID 89728Aminoacetaldehyde dimethyl acetal

生成物 1

HCID 10921057Ethyl 2,2-dimethoxyethylcarbamate

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 1140Toluene溶媒

実験手順

214 g (2 mol) of ethyl chloroformate are added dropwise to 214 g (2 mol) of aminoacetaldehyde dimethyl acetal in 1 l of toluene and 90 g of NaOH in 500 ml of water at 10° C. The mixture is stirred at room temperature for a further 2 hours and the aqueous phase is separated off, saturated with sodium chloride and extracted with toluene. The toluene solutions are dried over magnesium sulphate and concentrated and the residue is distilled.

後処理

  1. customthe aqueous phase is separated off, saturated with sodium chloride
  2. extractionextracted with toluene
  3. dry with materialThe toluene solutions are dried over magnesium sulphate
  4. concentrationconcentrated
  5. distillationthe residue is distilled

出典と根拠

ORDレコード
ord-9d97b7ac3ac0435c8feda74e2c76dc3b
出典データセット
uspto-grants-1995_05
特許番号
US05416096

関連ノート

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