HCID 69334832、化合物 → HCID 54495358、化合物
反応式
C([O:8][C:9]1[C:26]([N:27]([CH3:29])[CH3:28])=[CH:25][C:24]2[C@@H:23]3[C@H:14]([C@H:15]4[C@@:19]([CH2:21][CH2:22]3)([CH3:20])[C:18](=[O:30])[CH2:17][CH2:16]4)[CH2:13][CH2:12][C:11]=2[CH:10]=1)C1C=CC=CC=1>C1COCC1.[Pd]>[CH3:29][N:27]([CH3:28])[C:26]1[C:9]([OH:8])=[CH:10][C:11]2[CH2:12][CH2:13][C@@H:14]3[C@@H:23]([C:24]=2[CH:25]=1)[CH2:22][CH2:21][C@@:19]1([CH3:20])[C@H:15]3[CH2:16][CH2:17][C:18]1=[O:30]参加物
4
実験手順
To a solution of 3-benzyloxy-2-dimethylaminoestra-1,3,5(10)-trien-17-one (81, 0.666 g, 1.65 mmol) in THF (30 mL) was added 10% palladium on carbon (0.200 g). The reaction mixture was stirred for 1 h under a hydrogen atmosphere at room temperature. After the catalyst was filtered, the solvent was evaporated at reduced pressure. The residue was purified by column chromatography (silica gel) using n-hexane:EtOAc (3:1→2:1, v/v) to afford 0.462 g of 82 (89% yield) mp: 160-161° C.