[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.[I-].[Na+].[C:9](=[O:12])([O-])[O-].[K+].[K+].Br[CH:16]([CH3:18])[CH3:17].[CH:19](Cl)(Cl)Cl>CO>[C:9]([N:1]1[CH2:6][CH2:5][N:4]([CH:16]([CH3:18])[CH3:17])[CH2:3][CH2:2]1)(=[O:12])[CH3:19]To 12.95 g of piperazine, 0.75 g of sodium iodide and 3.46 g of potassium carbonate were added successively 25 ml of methanol and 6.15 g of 2-bromopropane and the mixture was stirred at 60° C. for 4 hours. After the addition of chloroform and washing with a saturated aqueous solution of sodium chloride, the mixture was dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure, 12 ml of acetic anhydride was slowly added and the mixture was stirred at room temperature for 2.5 hours. The reaction solution was poured into ice and chloroform was added and the mixture was neutralized with sodium carbonate. After extracting with chloroform, the extract was dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure and the residue thus obtained was chromatographed over a silica gel column. The solvent was distilled off and the residue was allowed to stand overnight. The diacetylpiperazine thus precipitated out was filtered off to afford 7.26 g of the title compound as an oily substance.
読み込み中…
