Water → 5-(Bromomethyl)benzo[d]oxazole

HRID 1004323ノート

反応式

HRID 1004323 の反応式
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH:8]=[N:7][C:6]=2[CH:10]=1.[Br:11]N1C(=O)CCC1=O.O>C(Cl)(Cl)Cl>[Br:11][CH2:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][CH:8]=[N:7][C:6]=2[CH:10]=1

参加物

5

反応物 3

HCID 962WaterHCID 67184N-bromobutanimideHCID 27249705-Methylbenzoxazole

生成物 1

HCID 219849815-(Bromomethyl)benzo[d]oxazole

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

A solution of 5-methylbenzoxazole (0.5 g) in chloroform (20 ml) containing N-bromosuccinimide (0.18 g) and azoisobutyronitrile (0.05 g) was refluxed for 2 hours. After allowing to cool to room temperature the reaction mixture was treated with water (30 ml). The organic phase was separated and the aqueous phase extracted with dichloromethane (30 ml). The combined organic phases were washed with brine (30 ml), dried over magnesium sulphate and evaporated. The residue was triturated with pentane giving the title compound (0.36 g) as an off-white solid, m.p. 90-93° C.

後処理

  1. temperaturewas refluxed for 2 hours
  2. customThe organic phase was separated
  3. extractionthe aqueous phase extracted with dichloromethane (30 ml)
  4. washThe combined organic phases were washed with brine (30 ml)
  5. dry with materialdried over magnesium sulphate
  6. customevaporated
  7. customThe residue was triturated with pentane giving the title compound (0.36 g) as an off-white solid, m.p. 90-93° C.

出典と根拠

ORDレコード
ord-42fa2a3da2d14b809218e78819ccab3c
出典データセット
uspto-grants-2000_04
特許番号
US06048893

反応ノート

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