Methanol → Methyl (2S)-piperidine-2-carboxylate--hydrogen chloride (1/1)

HRID 1006327

反応式

HRID 1006327 の反応式
S(Cl)([Cl:3])=O.[CH2:5]1[CH2:10][C@@H:9]([C:11]([OH:13])=[O:12])[NH:8][CH2:7][CH2:6]1.[CH3:14]O>>[ClH:3].[CH3:14][O:12][C:11]([C@@H:9]1[CH2:10][CH2:5][CH2:6][CH2:7][NH:8]1)=[O:13]

参加物

4

反応物 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 439227Pipecolic acid, (-)-

生成物 1

HCID 13246232Methyl (2S)-piperidine-2-carboxylate--hydrogen chloride (1/1)

反応条件

温度
55 °C

実験手順

Thionyl chloride (0.58 ml) was added dropwise to a solution of L-pipecolinic acid (450 mg) in methanol at room temperature. The reaction mixture was stirred at 55° C. for 2 hours. The whole mixture was evaporated under reduced pressure to give (2S)-piperidine-2-carboxylic acid methyl ester hydrochloride as a colorless oil.

後処理

  1. customThe whole mixture was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-6a6deb3a16944022b212e5e35fcbc918
出典データセット
uspto-grants-2004_09
特許番号
US06787543B2

関連ノート

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