2-Methoxybenzylamine → 3-(2-Methoxybenzylamino)-1,1-diphenylpropan-2-one

HRID 1006351

反応式

HRID 1006351 の反応式
Br[CH2:2][C:3](=[O:17])[CH:4]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1.[CH3:18][O:19][C:20]1[CH:27]=[CH:26][CH:25]=[CH:24][C:21]=1[CH2:22][NH2:23].C(N(CC)C(C)C)(C)C>O1CCCC1>[CH3:18][O:19][C:20]1[CH:27]=[CH:26][CH:25]=[CH:24][C:21]=1[CH2:22][NH:23][CH2:2][C:3](=[O:17])[CH:4]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1

参加物

5

反応物 3

HCID 812922-MethoxybenzylamineHCID 81531DiisopropylethylamineHCID 27946353-Bromo-1,1-diphenylacetone

生成物 1

HCID 226745333-(2-Methoxybenzylamino)-1,1-diphenylpropan-2-one

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

A solution of 3-bromo-1,1-diphenyl-2-propanone (0.5 g) in tetrahydrofuran (10 ml) was added to a mixture of (2-methoxy-benzyl)amine (1.13 ml) and N,N-diisopropylethylamine (0.602 ml) in tetrahydrofuran (12 ml) over 0.5 hour at room temperature. After being stirred at room temperature for 1.5 hours, the mixture was concentrated under reduced pressure to half volume and the resulting mixture was poured into ice-water (10 ml) and extracted with ethyl acetate (10 ml×2). The extract was washed with brine, dried over magnesium sulfate and evaporated under reduced pressure to give 3-[(2-methoxybenzyl)amino]-1,1-diphenylpropan-2-one (483 mg) as a colourless syrup.

後処理

  1. concentrationthe mixture was concentrated under reduced pressure to half volume
  2. additionthe resulting mixture was poured into ice-water (10 ml)
  3. extractionextracted with ethyl acetate (10 ml×2)
  4. washThe extract was washed with brine
  5. dry with materialdried over magnesium sulfate
  6. customevaporated under reduced pressure

出典と根拠

ORDレコード
ord-ff9512c27996433e964c07318633b344
出典データセット
uspto-grants-2004_09
特許番号
US06787543B2

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