Sodium Hydroxide → HCID 69023783、化合物

反応式

[C:1]([O:5][C:6]([NH:8][C@@H:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C@@H:10]1[NH:15][C:16]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([O:26][CH3:27])[CH:24]=2)[N:19]=[C:18]([C:28]([O:30]CC)=[O:29])[N:17]=1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[OH-].[Na+].S([O-])(O)(=O)=O.[K+]>CO>[C:1]([O:5][C:6]([NH:8][C@@H:9]1[CH2:14][CH2:13][CH2:12][CH2:11][C@@H:10]1[NH:15][C:16]1[C:25]2[C:20](=[CH:21][CH:22]=[C:23]([O:26][CH3:27])[CH:24]=2)[N:19]=[C:18]([C:28]([OH:30])=[O:29])[N:17]=1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

参加物

実験手順

A solution of 1.70 g of cis-N-tert-butoxycarbonyl-2-(2-ethoxycarbonyl-6-methoxyquinazolin-4-yl)aminocyclohexylamine in 5 mL of methanol was combined with 5 mL of a 1N aqueous solution of sodium hydroxide, and stirred at room temperature for 3 hours. After the pH was adjusted to 5 by addition of a 1N aqueous solution of potassium hydrogen sulfate to the reaction solution, which was then extracted with chloroform and dried. After the solvent was distilled off, the residue was purified by column chromatography on silica gel (chloroform:methanol=10:1) to obtain 1.10 g of the desirable compound.