Propylamine → N-(4-{[7-(Benzyloxy)-6-methoxy-4-quinazolinyl]oxy}-2-chlorophenyl)-N'-propylurea

HRID 1008341

反応式

[CH2:1]([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([O:19][C:20]3[CH:26]=[CH:25][C:23]([NH2:24])=[C:22]([Cl:27])[CH:21]=3)=[N:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[O:28][CH3:29])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.ClC(Cl)(O[C:41](=[O:47])OC(Cl)(Cl)Cl)Cl.[CH2:49]([NH2:52])[CH2:50][CH3:51]>C(Cl)(Cl)Cl>[CH2:1]([O:8][C:9]1[CH:18]=[C:17]2[C:12]([C:13]([O:19][C:20]3[CH:26]=[CH:25][C:23]([NH:24][C:41]([NH:52][CH2:49][CH2:50][CH3:51])=[O:47])=[C:22]([Cl:27])[CH:21]=3)=[N:14][CH:15]=[N:16]2)=[CH:11][C:10]=1[O:28][CH3:29])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

実験手順

4-{[7-(Benzyloxy)-6-methoxy-4-quinazolinyl]oxy}-2-chloroaniline (12.2 g) was dissolved in anhydrous chloroform. Triethylamine (8.4 ml) was then added to the solution, and the mixture was stirred at room temperature. Separately, triphosgene (4.5 g) was dissolved in anhydrous chloroform (12 ml), and the solution was added dropwise to the mixed solution. The mixture was stirred at room temperature for 20 min, and n-propylamine (4.9 ml) was then added thereto, followed by stirring at room temperature for additional one hr to precipitate a white solid. This solid was collected by filtration and was then washed with chloroform to give rib 9.4 g (yield 63%) of the title compound.

後処理

additionthe solution was added dropwise to the mixed solution
stirringThe mixture was stirred at room temperature for 20 min
stirringby stirring at room temperature for additional one hr
customto precipitate a white solid
filtrationThis solid was collected by filtration
washwas then washed with chloroform

出典と根拠

ORDレコード: ord-c1859057389c4602b7c7592af4c438bc
出典データセット: uspto-grants-2004_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US06797823B1

反応式

参加物

反応物 4

生成物 1

試薬・触媒・溶媒 1

実験手順

後処理

出典と根拠

関連ノート