Water → HCID 13540122、化合物
反応式
C([O:3][C:4]([C:6]1[S:10][C:9]2[CH:11]=[C:12]([CH2:15][OH:16])[CH:13]=[CH:14][C:8]=2[CH:7]=1)=[O:5])C.O.[Li+].[OH-]>C1COCC1>[OH:16][CH2:15][C:12]1[CH:13]=[CH:14][C:8]2[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[S:10][C:9]=2[CH:11]=1参加物
5
反応条件
- 温度
- 50 °C
実験手順
6-Hydroxymethyl-benzo[b]thiophene-2-carboxylic acid ethyl ester (2.4 g, 9.6 mmol, 1 eq) was dissolved in THF (10 mL, 4 vol) and water added (10 mL) along with LiOH (0.69 g, 28.8 mmol). The reaction mixture was stirred at 50° C. for 3 h and then concentrated to dryness and taken onto the next stage without purification.
後処理
- concentrationconcentrated to dryness
- customtaken onto the next stage without purification
出典と根拠
- ORDレコード
- ord-94d57f3a557840718557c030e454e098
- 出典データセット
- uspto-grants-2011_07
- 特許番号
- US07973181B2
反応ノート
読み込み中…