Sodium Hydroxide → 4-(4-tert-Butylanilino)-3-methoxy-2-methylpyridine

HRID 1010

反応式

HRID 1010 の反応式
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH3:8])[C:3]=1[O:9][CH3:10].[C:11]([C:15]1[CH:21]=[CH:20][C:18]([NH2:19])=[CH:17][CH:16]=1)([CH3:14])([CH3:13])[CH3:12].[OH-].[Na+]>C1(O)C=CC=CC=1>[C:11]([C:15]1[CH:16]=[CH:17][C:18]([NH:19][C:2]2[CH:7]=[CH:6][N:5]=[C:4]([CH3:8])[C:3]=2[O:9][CH3:10])=[CH:20][CH:21]=1)([CH3:14])([CH3:12])[CH3:13]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 698614-Tert-ButylanilineHCID 105830464-Chloro-3-methoxy-2-methylpyridine

生成物 1

HCID 196939534-(4-tert-Butylanilino)-3-methoxy-2-methylpyridine

試薬・触媒・溶媒 1

HCID 996Phenol溶媒

実験手順

7.9 g of 4-chloro-3-methoxy-2-methylpyridine and 22.4 g of 4-tert-butylaniline are heated at 120° C. for 8 hours in 20 g of phenol. After cooling, the mixture is poured into NaOH and the product is extracted using methylene chloride. After concentrating, the excess of amine is distilled off in vacuo and the residue is crystallized using hexane. 9.5 g=55%

後処理

  1. temperatureAfter cooling
  2. extractionthe product is extracted
  3. concentrationAfter concentrating
  4. distillationthe excess of amine is distilled off in vacuo
  5. customthe residue is crystallized

出典と根拠

ORDレコード
ord-ed5d30e63cae482aa9ed8a44a63361f9
出典データセット
uspto-grants-1998_03
特許番号
US05723450

関連ノート

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