Sodium Hydroxide → 4-(4-tert-Butylanilino)-3-methoxy-2-methylpyridine
反応式
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH3:8])[C:3]=1[O:9][CH3:10].[C:11]([C:15]1[CH:21]=[CH:20][C:18]([NH2:19])=[CH:17][CH:16]=1)([CH3:14])([CH3:13])[CH3:12].[OH-].[Na+]>C1(O)C=CC=CC=1>[C:11]([C:15]1[CH:16]=[CH:17][C:18]([NH:19][C:2]2[CH:7]=[CH:6][N:5]=[C:4]([CH3:8])[C:3]=2[O:9][CH3:10])=[CH:20][CH:21]=1)([CH3:14])([CH3:12])[CH3:13]参加物
5
実験手順
7.9 g of 4-chloro-3-methoxy-2-methylpyridine and 22.4 g of 4-tert-butylaniline are heated at 120° C. for 8 hours in 20 g of phenol. After cooling, the mixture is poured into NaOH and the product is extracted using methylene chloride. After concentrating, the excess of amine is distilled off in vacuo and the residue is crystallized using hexane. 9.5 g=55%
後処理
- temperatureAfter cooling
- extractionthe product is extracted
- concentrationAfter concentrating
- distillationthe excess of amine is distilled off in vacuo
- customthe residue is crystallized
出典と根拠
- ORDレコード
- ord-ed5d30e63cae482aa9ed8a44a63361f9
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05723450
反応ノート
読み込み中…