Lithium Hydroxide → 5-Methoxyquinoline-3-carboxylic acid

HRID 1011429ノート

反応式

HRID 1011429 の反応式
[CH2:1]([O:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[CH:11]=[C:12]([C:19]([O:21]CC)=[O:20])[CH:13]=[N:14]2)C1C=CC=CC=1.[Li+].[OH-]>C1COCC1.O>[CH3:1][O:8][C:9]1[CH:18]=[CH:17][CH:16]=[C:15]2[C:10]=1[CH:11]=[C:12]([C:19]([OH:21])=[O:20])[CH:13]=[N:14]2

参加物

5

反応物 2

HCID 3939Lithium HydroxideHCID 23159744HCID 23159744、化合物

生成物 1

HCID 231597415-Methoxyquinoline-3-carboxylic acid

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of ethyl 5-methoxyquinoline-3-carboxylate (2.31 g, 10 mmol) prepared in stage B of example 2 and LiOH (0.4 g, 20 mmol) in THF (20 mL) and water (0.5 mL) was refluxed for 2 hours. After cooling, the solvents were evaporated under vacuum. The solid residue was used in the next step without further purification.

後処理

  1. temperatureAfter cooling
  2. customthe solvents were evaporated under vacuum
  3. customThe solid residue was used in the next step without further purification

出典と根拠

ORDレコード
ord-28339260fa2744bba8e1de1f258a4b27
出典データセット
uspto-grants-2011_07
特許番号
US07977354B2

反応ノート

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