tert-Butanol → HCID 23159792、化合物

HRID 1011430ノート

反応式

HRID 1011430 の反応式
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][CH:10]=[C:9]2[C:4]=1[CH:5]=[C:6](C(O)=O)[CH:7]=[N:8]2.CC[N:18]([CH2:21]C)CC.N(P(=O)(OC1C=CC=CC=1)[O:27]C1C=CC=CC=1)=[N+]=[N-].[C:42]([OH:46])([CH3:45])([CH3:44])[CH3:43]>>[C:42]([O:46][C:21]([NH:18][C:6]1[CH:7]=[N:8][C:9]2[C:4]([CH:5]=1)=[C:3]([O:2][CH3:1])[CH:12]=[CH:11][CH:10]=2)=[O:27])([CH3:45])([CH3:44])[CH3:43]

参加物

5

反応物 4

HCID 6386tert-ButanolHCID 8471TriethylamineHCID 123414Diphenylphosphoryl azideHCID 231597415-Methoxyquinoline-3-carboxylic acid

生成物 1

HCID 23159792HCID 23159792、化合物

実験手順

To a solution of 5-methoxy-3-quinolinecarboxylic acid (2 g, 10 mmol) prepared in stage A of example 9 in tert-BuOH (15 mL) was added NEt3 (1.2 g, 12 mmol) and diphenyl azidophosphonate (DPPA) (2.1 mL, 10 mmol). The reaction mixture is refluxed for 24 hours. The solvent is evaporated under vacuum and the residue is dissolved in AcOEt (50 mL) and washed with a saturated NaHCO3 solution. After drying, the solvent is evaporated under vacuum affording the title compound.

後処理

  1. temperatureThe reaction mixture is refluxed for 24 hours
  2. customThe solvent is evaporated under vacuum
  3. dissolutionthe residue is dissolved in AcOEt (50 mL)
  4. washwashed with a saturated NaHCO3 solution
  5. customAfter drying
  6. customthe solvent is evaporated under vacuum

出典と根拠

ORDレコード
ord-508f4deec15345079de4055d83592843
出典データセット
uspto-grants-2011_07
特許番号
US07977354B2

反応ノート

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