Dimethyl Disulfide → HCID 23159742、化合物

HRID 1011434ノート

反応式

HRID 1011434 の反応式
Br[C:2]1[CH:3]=[N:4][C:5]2[C:10]([CH:11]=1)=[C:9]([O:12][CH3:13])[CH:8]=[CH:7][CH:6]=2.[CH3:14][S:15]SC>C1COCC1>[CH3:13][O:12][C:9]1[CH:8]=[CH:7][CH:6]=[C:5]2[C:10]=1[CH:11]=[C:2]([S:15][CH3:14])[CH:3]=[N:4]2

参加物

4

反応物 2

HCID 12232Dimethyl DisulfideHCID 231597643-Bromo-5-methoxyquinoline

生成物 1

HCID 23159742HCID 23159742、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
-78 °C

実験手順

To a solution of 3-bromo-5-methoxy quinoline (2.37 g, 10 mmol) prepared in stage B of example 10 in THF (25 mL) was added 2.5M n-buLi (4 mL, 10 mmol) at −78° C. The solution is stirred at −78° C. for 45 min and dimethyl disulfide (1.8 g, 20 mmol) is added. The resultant solution is stirred for 3 hours and then quenched with saturated NH4Cl (30 mL). Extraction with dichloromethane, drying, filtering and evaporation in vacuo afford the title compound

後処理

  1. customquenched with saturated NH4Cl (30 mL)
  2. extractionExtraction with dichloromethane
  3. customdrying
  4. filtrationfiltering
  5. customevaporation in vacuo

出典と根拠

ORDレコード
ord-602bdd1194b34418b09bb0bb9e75ce08
出典データセット
uspto-grants-2011_07
特許番号
US07977354B2

反応ノート

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