N-bromobutanimide → HCID 67315809、化合物

HRID 1013305ノート

反応式

HRID 1013305 の反応式
[C:1]1([CH3:20])[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[C:7]1[CH:15]=[CH:14][CH:13]=[C:12]2[C:8]=1[CH:9]=[C:10]([C:16]([O:18][CH3:19])=[O:17])[NH:11]2.[Br:21]N1C(=O)CCC1=O>ClCCl.O1CCCC1>[Br:21][C:9]1[C:8]2[C:12](=[CH:13][CH:14]=[CH:15][C:7]=2[C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][C:1]=2[CH3:20])[NH:11][C:10]=1[C:16]([O:18][CH3:19])=[O:17]

参加物

5

反応物 2

HCID 67184N-bromobutanimideHCID 67316099Methyl 4-o-tolyl-1h-indole-2-carboxylate

生成物 1

HCID 67315809HCID 67315809、化合物

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8028Tetrahydrofuran溶媒2 回

実験手順

To a solution of EXAMPLE 126A (205 mg) in dichloromethane (5 ml) and tetrahydrofuran (5 ml) at 0° C. was added dropwise N-bromosuccinimide (144 mg) in tetrahydrofuran (3 ml). The mixture was stirred while the ice bath slowly reached room temperature. The reaction mixture was concentrated and the residue was dissolved in dichloromethane and purified by flash chromatography, eluting with 0-100% dichloromethane in hexane to provide the desired product.

後処理

  1. concentrationThe reaction mixture was concentrated
  2. dissolutionthe residue was dissolved in dichloromethane
  3. custompurified by flash chromatography
  4. washeluting with 0-100% dichloromethane in hexane

出典と根拠

ORDレコード
ord-e970a1dd4af74878830c840d12a0a5f4
出典データセット
uspto-grants-2011_07
特許番号
US07981888B2

反応ノート

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