Oxalyl chloride → 7-phenylsulfanyl-3,4-dihydro-2H-naphthalen-1-one

4-(4-Phenylsulfanyl-phenyl)-butyric acid (5.0 g, 18.4 mmol) was dissolved in 50 mL tetrahydrofuran (THF). Oxalyl chloride (1.8 mL, 20 mmol) and one drop of DMF were added, and the reaction mixture was stirred for 1 hour, and then evaporated to dryness under reduced pressure. The resulting residue was dissolved in 40 mL of 1,2-dichloroethane, and aluminum trichloride (0.85 g, 25 mmol) was added all at once. The reaction mixture was stirred for 1 hour, and quenched by addition of 2% HCl. This aqueous mixture was extracted twice with 100 mL of EtOAc, and the combined organic layers were dried (MgSO4) and evaporated to yield 2.54 g (10 mmol, 55.5%) of 7-phenylsulfanyl-3,4-dihydro-2H-naphthalen-1-one as a gummy residue. MS: 255 (M+H)+.

1. customevaporated to dryness under reduced pressure
2. dissolutionThe resulting residue was dissolved in 40 mL of 1,2-dichloroethane
3. stirringThe reaction mixture was stirred for 1 hour
4. customquenched by addition of 2% HCl
5. extractionThis aqueous mixture was extracted twice with 100 mL of EtOAc
6. dry with materialthe combined organic layers were dried (MgSO4)
7. customevaporated

ORDレコード

ord-d1559e415b4748fe86a65a0901797ac2

出典データセット

uspto-grants-2011_07

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US07981923B2