Chloroacetyl chloride → HCID 246995、化合物

HRID 1014225ノート

反応式

HRID 1014225 の反応式
[CH3:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].C(N(CC)CC)C.[Cl:19][CH2:20][C:21](Cl)=[O:22]>C1COCC1>[Cl:19][CH2:20][C:21]([NH:6][C:5]1[CH:7]=[CH:8][C:2]([CH3:1])=[C:3]([N+:9]([O-:11])=[O:10])[CH:4]=1)=[O:22]

参加物

5

反応物 3

HCID 6577Chloroacetyl chlorideHCID 83904-Methyl-3-nitroanilineHCID 8471Triethylamine

生成物 1

HCID 246995HCID 246995、化合物収率 90%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution of 4-methyl-3-nitroaniline (1.0 g, 6.58 mmol, Lancaster), triethylamine (2.00 g, 19.7 mmol, Aldrich), and chloroacetyl chloride (0.96 g, 8.55 mmol) in THF (50 mL) was stirred overnight at rt. The reaction was washed with 1M HCl (50 mL), concentrated by rotary evaporation, and placed under high vacuum to give 2-chloro-N-(4-methyl-3-nitrophenyl)acetamide (1.35 g, 90%). ESIMS (M+H)+=229.

後処理

  1. washThe reaction was washed with 1M HCl (50 mL)
  2. concentrationconcentrated by rotary evaporation

出典と根拠

ORDレコード
ord-aea5b5ac0427433db5c7d298da7f3c6d
出典データセット
uspto-grants-2011_07
特許番号
US07981903B2

反応ノート

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