Sodium Carbonate → 4-(Thiazol-2-yl)cyclohexan-1-one
反応式
O1[C:5]2([CH2:10][CH2:9][CH:8]([C:11]3[S:12][CH:13]=[CH:14][N:15]=3)[CH2:7][CH2:6]2)[O:4]CC1.C([O-])([O-])=O.[Na+].[Na+]>C1COCC1>[S:12]1[CH:13]=[CH:14][N:15]=[C:11]1[CH:8]1[CH2:7][CH2:6][C:5](=[O:4])[CH2:10][CH2:9]1参加物
4
実験手順
A solution of 2-(1,4-dioxaspiro[4.5]dec-8-yl)-1,3-thiazole (0.21 g, 0.93 mmol) in 10 mL of THF/3NHCl (1:1) was stirred for 2 h at 50° C. After cooling to room temperature, the mixture was treated with Na2CO3 to pH 8 and extracted with EtOAc (3×). The combined organic layers were washed with saturated NaCl solution, dried (MgSO4), and concentrated to give 0.16 g of 4-(1,3-thiazol-2-yl)cyclohexanone in 95% yield. MS (EI) calcd: (M+H)+=182.1; found: 181.9.
後処理
- extractionextracted with EtOAc (3×)
- washThe combined organic layers were washed with saturated NaCl solution
- dry with materialdried (MgSO4)
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-1c3702beef604cf0b58917042de06832
- 出典データセット
- uspto-grants-2011_07
- 特許番号
- US07985730B2
反応ノート
読み込み中…