Hydrochloric Acid → 4-(4-Chlorobenzyl)piperidine

HRID 1016436

反応式

HRID 1016436 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([Cl:21])=[CH:17][CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.Cl.C(=O)([O-])[O-].[Na+].[Na+]>O1CCOCC1>[Cl:21][C:18]1[CH:17]=[CH:16][C:15]([CH2:14][CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[CH:20][CH:19]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 10340Sodium CarbonateHCID 22893851Tert-butyl 4-(4-chlorobenzyl)piperidine-1-carboxylate

生成物 1

HCID 37327804-(4-Chlorobenzyl)piperidine

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

A mixture of 2 g of 4-(4-chloro-benzyl)-piperidine-1-carboxylic acid tert-butyl ester, dioxane (1.5 mL), and 3N hydrochloric acid (1.0 mL, 4equiv.) was heated at reflux for 3.5 hours. The cooled mixture was made basic with saturated sodium carbonate solution and extracted with chloroform (3×10 mL). The combined extracts were dried over magnesium sulfate and concentrated under reduced pressure. The crude product (1.2 g) was an oil.

後処理

  1. temperaturewas heated
  2. temperatureat reflux for 3.5 hours
  3. extractionextracted with chloroform (3×10 mL)
  4. dry with materialThe combined extracts were dried over magnesium sulfate
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-a322db343dac44d1a4ef02ca7f9d00c2
出典データセット
uspto-grants-2002_11
特許番号
US06476041B1

関連ノート

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