Guaiacol → ((o-Methoxyphenoxy)methyl)oxirane

HRID 1017247ノート

反応式

HRID 1017247 の反応式
[C:1]1([O:8][CH3:9])[C:2](=[CH:4][CH:5]=[CH:6][CH:7]=1)[OH:3].CC(C)([O-])C.[K+].[CH2:16]([CH:18]1[O:20][CH2:19]1)Cl.C1OCCOCCOCCOCCOCCOC1>C(O)(C)(C)C.O>[O:20]1[CH2:19][CH:18]1[CH2:16][O:3][C:2]1[CH:4]=[CH:5][CH:6]=[CH:7][C:1]=1[O:8][CH3:9]

参加物

7

反応物 4

HCID 460GuaiacolHCID 7835EpichlorohydrinHCID 2855718-Crown-6HCID 23665647Potassium tert-butoxide

生成物 1

HCID 98357((o-Methoxyphenoxy)methyl)oxirane

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6386tert-Butanol溶媒

反応条件

温度
50 °C

実験手順

Guaiacol (8.6 g, 69 mmol), potassium t-butoxide (7.8 g, 69 mmol), epichlorohydrin (19.3 g, 209 mmol), and 18-crown-6 (0.8 g) were mixed in t-butanol (100 ml) and heated to 50° C. for 2 h. Water was added and the product was extracted with two portions of dichlorometane. Washing with water, twice, was followed by drying and evaporation. Quantitative yield.

後処理

  1. extractionthe product was extracted with two portions of dichlorometane
  2. washWashing with water
  3. customby drying
  4. customevaporation

出典と根拠

ORDレコード
ord-7f06efcd61404ef7987c209d8f77713a
出典データセット
uspto-grants-2002_11
特許番号
US06479491B1

反応ノート

読み込み中…