Sodium Hydroxide → 3-(3-Benzyl-3h-imidazol-4-yl)-1-(4-isobutylphenyl)-propen-1-one

HRID 1017743

反応式

HRID 1017743 の反応式
[CH3:1][CH:2]([CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]([CH3:13])=[O:12])=[CH:7][CH:6]=1)[CH3:3].[CH2:14]([N:21]1[C:25]([CH:26]=O)=[CH:24][N:23]=[CH:22]1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1.[OH-].[Na+]>CO>[CH2:14]([N:21]1[C:25]([CH:26]=[CH:13][C:11]([C:8]2[CH:7]=[CH:6][C:5]([CH2:4][CH:2]([CH3:1])[CH3:3])=[CH:10][CH:9]=2)=[O:12])=[CH:24][N:23]=[CH:22]1)[C:15]1[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 932144'-IsobutylacetophenoneHCID 27732391-Benzyl-1H-imidazole-5-carboxaldehyde

生成物 1

HCID 537079343-(3-Benzyl-3h-imidazol-4-yl)-1-(4-isobutylphenyl)-propen-1-one

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 4-isobutylacetophenone (2.0 g), 3-benzyl-3H-imidazole-4-carbaldehyde (2.1 g) and 48% sodium hydroxide (0.65 ml) in methanol (20 ml) is heated at 55-60° C. for 6 hours. The reaction mixture is then cooled in an ice bath. The resulting precipitate is filtered, and rinsed with methanol. The yield is 2.5 g.

後処理

  1. temperatureThe reaction mixture is then cooled in an ice bath
  2. filtrationThe resulting precipitate is filtered
  3. washrinsed with methanol

出典と根拠

ORDレコード
ord-ac275b4941a24169bdd390a2461dec08
出典データセット
uspto-grants-2002_11
特許番号
US06479530B2

関連ノート

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