Benzoyl Peroxide → 1-Butanone, 1-[4-(1-bromo-1-methylethyl)phenyl]-4-chloro-

HRID 1018071

反応式

HRID 1018071 の反応式
[Cl:1][CH2:2][CH2:3][CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([CH:13]([CH3:15])[CH3:14])=[CH:9][CH:8]=1)=[O:6].[Br:16]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:16][C:13]([C:10]1[CH:9]=[CH:8][C:7]([C:5](=[O:6])[CH2:4][CH2:3][CH2:2][Cl:1])=[CH:12][CH:11]=1)([CH3:15])[CH3:14]

参加物

5

反応物 3

HCID 7187Benzoyl PeroxideHCID 67184N-bromobutanimideHCID 987444-Chloro-4'-isopropylbutyrophenone

生成物 1

HCID 100635791-Butanone, 1-[4-(1-bromo-1-methylethyl)phenyl]-4-chloro-

試薬・触媒・溶媒 1

HCID 5943Carbon Tetrachloride溶媒

実験手順

Dissolve 4-chloro-1-(4-isopropyl-phenyl)-butan-1-one (2.10 g, 9.35 mmol) in carbontetrachloride (30 mL), add N-bromosuccinimide (1.75 g, 9.83 mmol) and benzoylperoxide (3 mg) and stir at reflux for 1 hour. Cool the reaction mixture, filter, wash with water and brine. Dry (MgSO4), filter and vaporate the solvent in vacuo to give the title compound as an amber oil.

後処理

  1. temperatureat reflux for 1 hour
  2. temperatureCool the reaction mixture
  3. filtrationfilter
  4. washwash with water and brine
  5. dry with materialDry (MgSO4)
  6. filtrationfilter

出典と根拠

ORDレコード
ord-0da1afb1fa93436892c181bd0e74b94f
出典データセット
uspto-grants-2002_11
特許番号
US06479663B2

関連ノート

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