Sodium Iodide → Propanoic acid, 2-methyl-, 1-iodoethyl ester
反応式
Cl[CH:2]([O:4][C:5](=[O:9])[CH:6]([CH3:8])[CH3:7])[CH3:3].[Na+].[I-:11]>CC#N>[I:11][CH:2]([O:4][C:5](=[O:9])[CH:6]([CH3:8])[CH3:7])[CH3:3]参加物
4
実験手順
To a solution of the chloro compound from Step 1 (2.6 g, 17.3 mmol) in CH3CN (20 mL) at r.t. was added NaI (2.85 g, 19 mmol). The flask was covered with Al foil and the reaction was stirred ON at r.t. The orange suspension was filtered and the filtrate was evaporated to dryness. The crude product was dissolved in Et2O/H2O and the organic phase was washed with aqueous sodium metabisulfite and brine. After drying (MgSO4), filtering, and removal of solvent, a pale brown oil (1.92 g) was obtained.
後処理
- filtrationThe orange suspension was filtered
- customthe filtrate was evaporated to dryness
- dissolutionThe crude product was dissolved in Et2O/H2O
- washthe organic phase was washed with aqueous sodium metabisulfite and brine
- dry with materialAfter drying (MgSO4)
- filtrationfiltering
- customremoval of solvent
出典と根拠
- ORDレコード
- ord-94e4cba280d846c698823ff719093957
- 出典データセット
- uspto-grants-2002_11
- 特許番号
- US06486142B2
反応ノート
読み込み中…