Water → HCID 57461817、化合物

HRID 1020384ノート

反応式

HRID 1020384 の反応式
Cl[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][N:3]=1.[N:11]1[N:12]=[C:13]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[N:14]2[CH2:19][CH2:18][NH:17][CH2:16][C:15]=12.C(N(C(C)C)CC)(C)C.O>C(#N)C>[N+:8]([C:5]1[CH:6]=[CH:7][C:2]([N:17]2[CH2:18][CH2:19][N:14]3[C:13]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[N:12][N:11]=[C:15]3[CH2:16]2)=[N:3][CH:4]=1)([O-:10])=[O:9]

参加物

6

反応物 4

HCID 962WaterHCID 783082-Chloro-5-nitropyridineHCID 81531DiisopropylethylamineHCID 17998728Ethyl 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-A]pyrazine-3-carboxylate

生成物 1

HCID 57461817HCID 57461817、化合物収率 75%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

反応条件

温度
80 °C

実験手順

2-Chloro-5-nitropyridine (0.97 g, 5.5 mmol), ethyl 5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-3-carboxylate (1.0 g, 5.1 mmol), and diisopropylethylamine (2 mL) were mixed in acetonitrile (5 mL), and heated to 80° C. for one h. The mixture was poured into water, and the precipitate was collected by filtration. The precipitate was washed with water, then by ether, and dried in a vacuum oven overnight to give 1.2 gram of product C-12 (75% yield).

後処理

  1. filtrationthe precipitate was collected by filtration
  2. washThe precipitate was washed with water
  3. dry with materialby ether, and dried in a vacuum oven overnight

出典と根拠

ORDレコード
ord-df2e37022a6f46679762d25af7c59326
出典データセット
uspto-grants-2014_05
特許番号
US08716312B2

反応ノート

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