Diisopropylethylamine → HCID 86630519、化合物

HRID 1022418ノート

反応式

HRID 1022418 の反応式
[C:1]([O:5][C:6](=[O:33])[C:7]1[CH:19]=[C:18]([O:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30]([OH:32])=[O:31])[CH:17]=[C:9]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH:8]=1)([CH3:4])([CH3:3])[CH3:2].[B-](F)(F)(F)F.CN(C(O[N:47]1[C:52](=[O:53])[CH2:51][CH2:50][C:48]1=[O:49])=[N+](C)C)C.CCN(C(C)C)C(C)C>C1COCC1>[C:1]([O:5][C:6](=[O:33])[C:7]1[CH:19]=[C:18]([O:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][C:30]([O:32][N:47]2[C:52](=[O:53])[CH2:51][CH2:50][C:48]2=[O:49])=[O:31])[CH:17]=[C:9]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH:8]=1)([CH3:2])([CH3:3])[CH3:4]

参加物

5

反応物 3

HCID 81531DiisopropylethylamineHCID 98575222-(2,5-Dioxopyrrolidin-1-yl)-1,1,3,3-tetramethylisouronium tetrafluoroborateHCID 684432455-(9-Carboxy-nonyloxy)-isophthalic Acid Di-tert-butyl Ester

生成物 1

HCID 86630519HCID 86630519、化合物

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 5-(9-Carboxy-nonyloxy)-isophthalic acid di-tert-butyl ester (156 mg, 0.34 mmol) in dry THF (2 ml) was added TSTU (125 mg) and DIPEA (0.08 ml). The mixture was stirred under nitrogen over night. The mixture was concentrated. The residue was redissolved in EtOAc and filtered. The filtrate was washed with 0.1N HCl (2×), and brine (1×), dried (Na2SO4) and concentrated to give a clear syrup.

後処理

  1. concentrationThe mixture was concentrated
  2. dissolutionThe residue was redissolved in EtOAc
  3. filtrationfiltered
  4. washThe filtrate was washed with 0.1N HCl (2×), and brine (1×)
  5. dry with materialdried (Na2SO4)
  6. concentrationconcentrated
  7. customto give a clear syrup

出典と根拠

ORDレコード
ord-896b0a38e55446c48d3b0592f6dbd555
出典データセット
uspto-grants-2014_05
特許番号
US08722620B2

反応ノート

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