Sodium hydride → 4-chloro-2-[[(2,3-difluorophenyl)methyl]thio]-6-[(1R)-1-methyl-2-(triphenylmethoxy)ethoxy]-pyrimidine

HRID 1024858ノート

反応式

HRID 1024858 の反応式
[C:1]1([C:7]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[O:8][CH2:9][C@H:10]([OH:12])[CH3:11])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:25][C:26]1[CH:31]=[C:30](Cl)[N:29]=[C:28]([S:33][CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[C:37]([F:41])[C:36]=2[F:42])[N:27]=1.[H-].[Na+]>C1COCC1>[Cl:25][C:26]1[CH:31]=[C:30]([O:12][C@H:10]([CH3:11])[CH2:9][O:8][C:7]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)([C:13]2[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=2)[C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:29]=[C:28]([S:33][CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[C:37]([F:41])[C:36]=2[F:42])[N:27]=1

参加物

5

反応物 3

HCID 24758Sodium hydrideHCID 11067110(2R)-1-(triphenylmethoxy)-2-propanolHCID 859280374,6-Dichloro-2-((2,3-difluorobenzyl)thio)pyrimidine

生成物 1

HCID 536283454-chloro-2-[[(2,3-difluorophenyl)methyl]thio]-6-[(1R)-1-methyl-2-(triphenylmethoxy)ethoxy]-pyrimidine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

The subtitle compound was prepared according to the procedure outlined in example 1 step (iii) using (2R)-1-(triphenylmethoxy)-2-propanol (1.35 g) and 4,6-Dichloro-2-[(2,3-difluorobenzyl)thio]pyrimidine (the product of example 1 step (ii) (1 g) in THF (15 mL) and 60% sodium hydride (0.18 g) to give the subtitle compound as a pale yellow oil. Yield: 1.8 g.

後処理

  1. customThe subtitle compound was prepared

出典と根拠

ORDレコード
ord-15bab7326cfe4376b2cd9f6ddab43110
出典データセット
uspto-grants-2014_05
特許番号
US08722883B2

反応ノート

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