Sodium hydride → HCID 53628391、化合物
反応式
Cl[C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([S:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[C:12]=2[F:18])[N:3]=1.[Si:19]([O:26][CH2:27][C@H:28]([OH:34])[CH2:29][O:30][CH:31]([CH3:33])[CH3:32])([C:22]([CH3:25])([CH3:24])[CH3:23])([CH3:21])[CH3:20].[H-].[Na+]>C1COCC1>[Si:19]([O:26][CH2:27][C@@H:28]([CH2:29][O:30][CH:31]([CH3:33])[CH3:32])[O:34][C:2]1[CH:7]=[C:6]([Cl:8])[N:5]=[C:4]([S:9][CH2:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[C:12]=2[F:18])[N:3]=1)([C:22]([CH3:25])([CH3:24])[CH3:23])([CH3:21])[CH3:20]参加物
5
実験手順
The subtitle compound was prepared according to the procedure outlined in example 1 step iii) using 4,6-Dichloro-2-[(2,3-difluorobenzyl)thio]pyrimidine (product of example 1 step ii) (0.46 g), (2R)-1-{[tert-butyl(dimethyl)silyl]oxy}-3-isopropoxypropan-2-ol (product of step iii) (0.66 g), THF (5 mL) and 60% sodium hydride (80 mg), to give the subtitle compound as a colourless oil. Yield: 0.56 g