Sodium Hydroxide → 1-(Diphenylmethyl)azetidine-3-carboxylic acid

HRID 1029635ノート

反応式

HRID 1029635 の反応式
[C:1]1([CH:7]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:8]2[CH2:11][CH:10]([C:12]([O:14]C)=[O:13])[CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>CO.O1CCCC1>[C:16]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[N:8]2[CH2:11][CH:10]([C:12]([OH:14])=[O:13])[CH2:9]2)[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1

参加物

5

反応物 2

HCID 14798Sodium HydroxideHCID 2759842Methyl 1-(diphenylmethyl)azetidine-3-carboxylate

生成物 1

HCID 27354401-(Diphenylmethyl)azetidine-3-carboxylic acid収率 92.8%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 1-(diphenylmethyl)-3-methoxycarbonylazetidine (28 g) in methanol (270 ml) and tetrahydrofuran (130 ml) was added 1N sodium hydroxide (115 ml) and the solution was stirred at room temperature for 1.5 hours. The solution was then concentrated to remove organic solvents under reduced pressure. The resultant aqueous solution was adjusted to pH 2.95 with 10% hydrochloric acid, and resulting precipitates were collected by filtration, washed with water and dried to give 1-(diphenylmethyl)-3-carboxyazetidine (24.7 g).

後処理

  1. concentrationThe solution was then concentrated
  2. customto remove organic solvents under reduced pressure
  3. customresulting
  4. customprecipitates
  5. filtrationwere collected by filtration
  6. washwashed with water
  7. customdried

出典と根拠

ORDレコード
ord-eb6769a95d484a969b52426dd2c14f2b
出典データセット
uspto-grants-1992_04
特許番号
US05102877

反応ノート

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