Hydrogen Sulfide → 3,5-Di-tert-butyl-4-hydroxyphenyl thioacetamide

HRID 1030226ノート

反応式

HRID 1030226 の反応式
[C:1]([C:5]1[CH:6]=[C:7]([CH2:16][C:17]#[N:18])[CH:8]=[C:9]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:10]=1[OH:11])([CH3:4])([CH3:3])[CH3:2].C(N(CC)CC)C.[SH2:26]>N1C=CC=CC=1>[C:12]([C:9]1[CH:8]=[C:7]([CH2:16][C:17]([NH2:18])=[S:26])[CH:6]=[C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])[C:10]=1[OH:11])([CH3:15])([CH3:14])[CH3:13]

参加物

5

反応物 3

HCID 402Hydrogen SulfideHCID 8471TriethylamineHCID 615568(3,5-Di-tert-butyl-4-hydroxyphenyl)acetonitrile

生成物 1

HCID 146278133,5-Di-tert-butyl-4-hydroxyphenyl thioacetamide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

3,5-Di-tert-butyl-4-hydroxyphenylacetonitrile (20.0 g) and 11.4 ml of triethylamine were dissolved in 40 ml of pyridine, and hydrogen sulfide was blown into the solution at room temperature over 13 hours. The reaction mixture was concentrated, and the crude product thus obtained was purified by silica gel column chromatography (diethyl ether-hexane =3:7) to give 4.9 g of the desired compound as a colorless solid.

後処理

  1. concentrationThe reaction mixture was concentrated
  2. customthe crude product thus obtained
  3. customwas purified by silica gel column chromatography (diethyl ether-hexane =3:7)

出典と根拠

ORDレコード
ord-233302ed76be423e8e7ebd794f843162
出典データセット
uspto-grants-1992_04
特許番号
US05104889

反応ノート

読み込み中…