Thionyl Chloride → Ethyl 4-(3-chloro-3-oxopropyl)-1-piperidinecarboxylate
反応式
[CH2:1]([O:3][C:4]([N:6]1[CH2:11][CH2:10][CH:9]([CH2:12][CH2:13][C:14]([OH:16])=O)[CH2:8][CH2:7]1)=[O:5])[CH3:2].S(Cl)([Cl:19])=O>ClC(Cl)Cl>[Cl:19][C:14](=[O:16])[CH2:13][CH2:12][CH:9]1[CH2:10][CH2:11][N:6]([C:4]([O:3][CH2:1][CH3:2])=[O:5])[CH2:7][CH2:8]1参加物
4
実験手順
To a stirred mixture of 200 parts of 1-(ethoxycarbonyl)-4-piperidinepropanoic acid and 750 parts of trichloromethane were added 320 parts of thionyl chloride. The whole was stirred for 18 hours at room temperature. The reaction mixture was evaporated with methylbenzene. The residue was distilled, yielding 102.6 parts (47%) of ethyl 4-(3-chloro-3-oxopropyl)-1-piperidinecarboxylate; bp. 165-170 at 399 Pa (int. 45).
後処理
- customThe reaction mixture was evaporated with methylbenzene
- distillationThe residue was distilled
出典と根拠
- ORDレコード
- ord-13cfa60d02434a76a9616d632ba7491c
- 出典データセット
- uspto-grants-1992_04
- 特許番号
- US05106973
反応ノート
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