[6-(1H-Imidazol-1-yl)pyridin-3-yl]methanol → 6-(1H-iMidazol-1-yl)nicotinaldehyde
反応式
[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([CH2:12][OH:13])=[CH:8][N:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1>C(Cl)(Cl)Cl.O=[Mn]=O>[N:1]1([C:6]2[CH:11]=[CH:10][C:9]([CH:12]=[O:13])=[CH:8][N:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1参加物
4
実験手順
MnO2 (18.17 g) is added to a solution of the hydroxy methyl compound of Step 3. above (6.1 g) in CHCl3, and the resulting reaction mixture heated to reflux for 22 hours, allowed to cool, filtered, and the organic layer evaporated affording the desired product as a white solid used in the next step without further purification. M.P.=139.5°-140.5° C.
後処理
- temperatureheated
- temperatureto reflux for 22 hours
- temperatureto cool
- filtrationfiltered
- customthe organic layer evaporated
出典と根拠
- ORDレコード
- ord-ec499654870d41699ff01b4c1ff1ecb1
- 出典データセット
- uspto-grants-1990_09
- 特許番号
- US04954494
反応ノート
読み込み中…