Hydrochloric Acid → (4-(Benzyloxy)-3-nitrophenyl)methanol

HRID 1032512

反応式

HRID 1032512 の反応式
[BH4-].[Na+].[CH2:3]([O:10][C:11]1[CH:18]=[CH:17][C:14]([CH:15]=[O:16])=[CH:13][C:12]=1[N+:19]([O-:21])=[O:20])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.Cl>CO>[CH2:3]([O:10][C:11]1[CH:18]=[CH:17][C:14]([CH2:15][OH:16])=[CH:13][C:12]=1[N+:19]([O-:21])=[O:20])[C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 4311764Sodium borohydrideHCID 70235544-(Benzyloxy)-3-nitrobenzaldehyde

生成物 1

HCID 13629301(4-(Benzyloxy)-3-nitrophenyl)methanol収率 79.8%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

Under ice cooling, 75.7 g of sodium borohydride is introduced within one hour into 128.0 g of 4-benzyloxy-3-nitrobenzaldehyde in 4.2 l of methanol. After 1.5 hours of agitation at room temperature, 1.1 l of 2N HCl is added dropwise. The isolated reaction product is recrystallized from a mixture of 680 ml of diisopropyl ether and 170 ml of isopropanol, thus obtaining 103.0 g of 4-benzyloxy-3-nitrobenzyl alcohol, mp 76°-77° C.

後処理

  1. customThe isolated reaction product
  2. customis recrystallized from a mixture of 680 ml of diisopropyl ether and 170 ml of isopropanol

出典と根拠

ORDレコード
ord-332bfc4ec5674ccebc0f9df332c27bfd
出典データセット
uspto-grants-1990_09
特許番号
US04958026

関連ノート

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