Thionyl Chloride → 4-Benzyloxy-3-nitrobenzyl chloride

HRID 1032513

反応式

HRID 1032513 の反応式
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13]O)=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.S(Cl)([Cl:22])=O>>[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13][Cl:22])=[CH:11][C:10]=1[N+:17]([O-:19])=[O:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 13629301(4-(Benzyloxy)-3-nitrophenyl)methanol

生成物 1

HCID 136293024-Benzyloxy-3-nitrobenzyl chloride

実験手順

Under agitation, 58.3 g of 4-benzyloxy-3-nitrobenzyl alcohol is introduced in incremental portions into 250 ml of thionyl chloride, stirred for 30 minutes at room temperature, and concentrated under vacuum. The residue is recrystallized from diisopropyl ether while decolorizing with active carbon, thus producing 50.9 g of 4-benzyloxy-3-nitrobenzyl chloride, mp 60°-61° C.

後処理

  1. concentrationconcentrated under vacuum
  2. customThe residue is recrystallized from diisopropyl ether

出典と根拠

ORDレコード
ord-f154fe0b6dc34555ac16b885a6de168a
出典データセット
uspto-grants-1990_09
特許番号
US04958026

関連ノート

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