ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

Ammonia → 2,4-Diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-chloropyrido[2,3-d]pyrimidine

HRID 1032817
ノート
印刷プレビュー

反応式

HRID 1032817 の反応式
[NH2:1][C:2]1[N:3]=[C:4]([NH2:25])[C:5]2[C:11]([CH3:12])=[C:10]([CH2:13][C:14]3[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:15]=3[O:22][CH3:23])[C:9](=O)[NH:8][C:6]=2[N:7]=1.C[N+](C)=C[Cl:29].[Cl-].S(Cl)(Cl)=O.N1C2C=CC=NC=2C=NC=1.N>C(Cl)(Cl)Cl.CN(C)C=O>[NH2:1][C:2]1[N:3]=[C:4]([NH2:25])[C:5]2[C:11]([CH3:12])=[C:10]([CH2:13][C:14]3[CH:19]=[C:18]([O:20][CH3:21])[CH:17]=[CH:16][C:15]=3[O:22][CH3:23])[C:9]([Cl:29])=[N:8][C:6]=2[N:7]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

8

反応物 5

HCID 222AmmoniaHCID 24386Thionyl ChlorideHCID 77311Chloro-N,N-dimethylformiminium chloride2 回HCID 125974832,4-Diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidineHCID 17882607Pyrido(3,2-d)pyrimidine

生成物 1

HCID 12597484
2,4-Diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-chloropyrido[2,3-d]pyrimidine

試薬・触媒・溶媒 2

HCID 6212Chloroform溶媒2 回HCID 6228Dimethylformamide溶媒

実験手順

2,4-Diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine (8 g) was chlorinated by treatment with Vilsmeier reagent prepared by slowly adding thionyl chloride (28.6) in dry chloroform (25 ml) to a solution of dimethylformamide (17.5) in chloroform (100 ml) at 0°-5° C. The cold mixture of the pyridopyrimidine and Vilsmeier reagent was stirred, gradually allowed to reach ambient temperatures and then heated at reflux for 3 hours. It was then treated with ethanolic base (80 ml) maintaining the temperature at 25°-30° C. with cooling. The brown product formed was isolated, treated further with aqueous ammonia and then recrystallized from ethanol to give 2,4-diamino-5-methyl-6-(2,5-dimethoxybenzyl)-7-chloropyrido[2,3-d]pyrimidine, m.p. 193°-196° (dec.).

後処理

  1. temperatureheated
  2. temperatureat reflux for 3 hours
  3. temperaturemaintaining the temperature at 25°-30° C.
  4. temperaturewith cooling
  5. customThe brown product formed
  6. customwas isolated
  7. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-fc8abb684b0c49ae856e9df633ee733f
出典データセット
uspto-grants-1990_09
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04959474

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート