Nitromethane → 2-Methoxy-3-(2-nitroethenyl)-5-ethyl-6-methylpyridine
反応式
[CH3:1][O:2][C:3]1[N:10]=[C:9]([CH3:11])[C:8]([CH2:12][CH3:13])=[CH:7][C:4]=1[CH:5]=O.[N+:14]([CH3:17])([O-:16])=[O:15].Cl.CN.[OH-].[Na+]>C(O)C.CO>[CH3:1][O:2][C:3]1[C:4]([CH:5]=[CH:17][N+:14]([O-:16])=[O:15])=[CH:7][C:8]([CH2:12][CH3:13])=[C:9]([CH3:11])[N:10]=1参加物
7
実験手順
A mixture of 2-methoxy-5-ethyl-6-methylnicotinaldehyde (2.25 g, 12.6 mmol), nitromethane (1.9 g, 31.1 mmol), monomethylamine hydrochloride (69 mg) and sodium hydroxide (20 mg) in absolute ethanol (1.3 mL) was stirred at ambient temperature for three days. This mixture was diluted with methanol and the precipitated yellow crystalline product was collected by filtration to yield 2.39 g (86%), m.p. 105°-107° C.
後処理
- filtrationthe precipitated yellow crystalline product was collected by filtration
- customto yield 2.39 g (86%), m.p. 105°-107° C.
出典と根拠
- ORDレコード
- ord-82781bfacc6b4987961c3f7bbaf07d2a
- 出典データセット
- uspto-grants-1994_05
- 特許番号
- US05308854
反応ノート
読み込み中…