Diethyl Ether → 2-ethoxycarbonyl-5-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridinium iodide

HRID 1033748ノート

反応式

HRID 1033748 の反応式
[CH2:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH2:3][N:2]1[C:10]([O:12][CH2:13][CH3:14])=[O:11].C[I:16].[CH2:17](OCC)C>C(#N)C>[I-:16].[CH2:13]([O:12][C:10]([NH+:2]1[CH2:1][C:9]2[CH:8]=[CH:7][N:6]([CH3:17])[CH2:5][C:4]=2[CH2:3]1)=[O:11])[CH3:14]

参加物

5

反応物 3

HCID 3283Diethyl EtherHCID 6328Methyl iodideHCID 18953633ethyl 1H-pyrrolo[3,4-c]pyridine-2(3H)-carboxylate

生成物 1

HCID 678240962-ethoxycarbonyl-5-methyl-2,3-dihydro-1H-pyrrolo[3,4-c]pyridinium iodide

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

9.6 g (50 mmol) of ethyl 2,3-dihydro-1H-pyrrolo-[3,4-c]pyridine-2-carboxylate and 6.3 ml (100 mmol) of methyl iodide are refluxed for 15 hours in 50 ml of acetonitrile. The batch is poured into diethyl ether, and the salt which has precipitated is filtered off with suction and dried in the air.

後処理

  1. customthe salt which has precipitated
  2. filtrationis filtered off with suction
  3. customdried in the air

出典と根拠

ORDレコード
ord-59124bde501248bdb147f9bb83755fba
出典データセット
uspto-grants-1994_05
特許番号
US05312823

反応ノート

読み込み中…