Hydroxyamine hydrochloride → Ethyl 4-(hydroxyimino)-5-oxo-1-phenyl-3-pyrrolidineacetate
反応式
O=[C:2]1[C:6](=[O:7])[N:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:4][CH:3]1[CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16].Cl.[NH2:21][OH:22]>N1C=CC=CC=1>[OH:22][N:21]=[C:2]1[C:6](=[O:7])[N:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:4][CH:3]1[CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16]参加物
4
実験手順
A solution of product of Example 62 in pyridine is treated with an excess of hydroxylamine hydrochloride and the reaction is stirred at room temperature for 2 d. The solution is concentrated in vacuo and the residue is chromatographed on silica gel to give the title compound.
後処理
- concentrationThe solution is concentrated in vacuo
- customthe residue is chromatographed on silica gel
出典と根拠
- ORDレコード
- ord-0d580ab7493b40a79fc2fcb7b240b71d
- 出典データセット
- uspto-grants-1994_05
- 特許番号
- US05314886
反応ノート
読み込み中…