N-bromobutanimide → 1,6-Dibromo-2-methoxy-naphthalene
反応式
[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH:8]=[C:7]([O:12][CH3:13])[CH:6]=[CH:5]2.C1C(=O)N([Br:21])C(=O)C1>C1COCC1>[Br:21][C:8]1[C:9]2[C:4](=[CH:3][C:2]([Br:1])=[CH:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[O:12][CH3:13]参加物
4
実験手順
6-Bromo-2-methoxynaphthalene (5.9 g, 24.81 mmol, 1 eq) and NBS (4.41, 24.81 mmol, 1 eq) are boiled in 50 ml of THF under reflux for 2 h. After washing with 1 N HCl, the organic phase is dried over magnesium sulfate, filtered and concentrated in vacuum on a rotary evaporator. The compound is obtained in quantitative yield (7.8 g).
後処理
- temperatureunder reflux for 2 h
- washAfter washing with 1 N HCl
- dry with materialthe organic phase is dried over magnesium sulfate
- filtrationfiltered
- concentrationconcentrated in vacuum on a rotary evaporator
- customThe compound is obtained in quantitative yield (7.8 g)
出典と根拠
- ORDレコード
- ord-7529570b0a404868bf016225143e0a81
- 出典データセット
- uspto-grants-2013_10
- 特許番号
- US08546392B2
反応ノート
読み込み中…