N-bromobutanimide → 5,6-Dibromo-2,3-dihydrobenzofuran
反応式
C1C(=O)N([Br:8])C(=O)C1.[Br:9][C:10]1[CH:11]=[CH:12][C:13]2[CH2:17][CH2:16][O:15][C:14]=2[CH:18]=1>C(#N)C>[Br:8][C:11]1[C:10]([Br:9])=[CH:18][C:14]2[O:15][CH2:16][CH2:17][C:13]=2[CH:12]=1参加物
4
実験手順
NBS (450 mg, 2.53 mmol) was added to a solution of 6-bromo-2,3-dihydrobenzo[b]furan (137) (504 mg, 2.53 mmol) in 15 ml ACN. The reaction mixture was stirred overnight at r.t. The yellow solution was poured into ice-water, extracted with EA. Org. phase was washed with aq. sodium bicarbonate and brine subsequently. After dried over sodium sulfate the org. phase was concentrated to give 676 mg (purity ca. 90%) title compound as dark oil which solidified after standing at r.t.
後処理
- extractionextracted with EA
- washphase was washed with aq. sodium bicarbonate and brine subsequently
- dry with materialAfter dried over sodium sulfate the org
- concentrationphase was concentrated
出典と根拠
- ORDレコード
- ord-6261de30ab2b4d1286b75c9d56757b55
- 出典データセット
- uspto-grants-2013_10
- 特許番号
- US08546403B2
反応ノート
読み込み中…