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Sodium Thiosulfate → 2-(2-Amino-pyrimidin-4-yl)-3-iodo-4-oxo-1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridine-5-carboxylic acid tert-butyl ester

HRID 1036588
ノート
印刷プレビュー

反応式

HRID 1036588 の反応式
[I:1]N1C(=O)CCC1=O.[C:9]([O:13][C:14]([N:16]1[CH2:21][CH2:20][C:19]2[NH:22][C:23]([C:25]3[CH:30]=[CH:29][N:28]=[C:27]([NH2:31])[N:26]=3)=[CH:24][C:18]=2[C:17]1=[O:32])=[O:15])([CH3:12])([CH3:11])[CH3:10].[Al].[O-]S([O-])(=S)=O.[Na+].[Na+]>CN(C=O)C>[C:9]([O:13][C:14]([N:16]1[CH2:21][CH2:20][C:19]2[NH:22][C:23]([C:25]3[CH:30]=[CH:29][N:28]=[C:27]([NH2:31])[N:26]=3)=[C:24]([I:1])[C:18]=2[C:17]1=[O:32])=[O:15])([CH3:12])([CH3:10])[CH3:11]
参加物実験手順後処理出典と根拠反応ノート

参加物

6

反応物 4

HCID 24477Sodium ThiosulfateHCID 120273N-IodosuccinimideHCID 5359268AluminumHCID 247769152-(2-Amino-pyrimidin-4-yl)-4-oxo-1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridine-5-carboxylic acid tert-butyl ester

生成物 1

HCID 672844762-(2-Amino-pyrimidin-4-yl)-3-iodo-4-oxo-1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridine-5-carboxylic acid tert-butyl ester収率 90%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

N-iodo succinimide (0.75 g, 3.34 mml) was added to a solution of 2-(2-amino-pyrimidin-4-yl)-4-oxo-1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridine-5-carboxylic acid tert-butyl ester [(1), Q=Boc] (1.0 g, 3.03 mmol) in dry DMF (15 mL) and the reaction mixture was stirred at room temperature overnight, in a flask surrounded by an aluminium sheet. After reaction completion, a solution of Na2S2O3 (10%, 0.100 ml) was added and the product was extracted with DCM (3×0.100 mL). The organic layer was dried over Na2SO4 and the solvent was removed under reduced pressure to yield the crude 2-(2-amino-pyrimidin-4-yl)-3-iodo-4-oxo-1,4,6,7-tetrahydro-pyrrolo[3,2-c]pyridine-5-carboxylic acid tert-butyl ester as a yellow solid (1.240 g, 2.72 mmol, 90%).

後処理

  1. customAfter reaction completion
  2. extractionthe product was extracted with DCM (3×0.100 mL)
  3. dry with materialThe organic layer was dried over Na2SO4
  4. customthe solvent was removed under reduced pressure

出典と根拠

ORDレコード
ord-7cbad1df20ba4e26af942d051b2145ed
出典データセット
uspto-grants-2013_10
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08546413B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート