Hydroxyamine hydrochloride → HCID 89573941、化合物

HRID 1037068ノート

反応式

HRID 1037068 の反応式
[CH:1]([C:3]1[N:4]2[C:8]([C:9]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:11]=1)=[CH:7][CH:6]=[CH:5]2)=O.[NH2:16][OH:17].Cl.CC([O-])=O.[Na+]>C1COCC1.O>[OH:17]/[N:16]=[CH:1]/[C:3]1[N:4]2[C:8]([C:9]([C:12]([O:14][CH3:15])=[O:13])=[CH:10][CH:11]=1)=[CH:7][CH:6]=[CH:5]2

参加物

6

反応物 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 86685513Methyl 5-formylindolizine-8-carboxylate

生成物 1

HCID 89573941HCID 89573941、化合物

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of methyl 5-formylindolizine-8-carboxylate (203 mg, 1.0 mmol) and NH2OH.HCl (105 mg, 1.5 mmol) in THF (30 mL) and H2O (8 mL) at rt was added NaOAc (164 mg, 2.0 mmol). The reaction mixture was stirred at rt for 2 h. The mixture was extracted with EA (2×40 mL). The organic layers was dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was used in next step without further purification.

後処理

  1. extractionThe mixture was extracted with EA (2×40 mL)
  2. dry with materialThe organic layers was dried over Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated under reduced pressure
  5. customThe residue was used in next step without further purification

出典と根拠

ORDレコード
ord-8095406ef31b411c8de29b3c599cb6fe
出典データセット
uspto-grants-2013_10
特許番号
US08546357B2

反応ノート

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